The estrogen-regulated transcriptome: rapid, robust, extensive, and transient

Yasmin M. Vasquez, W. Lee Kraus

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

The steroid hormone estrogen has potent effects in a variety of tissues across the body in both females and males. In the nuclear signaling pathway for estrogens, the hormone acts by stimulating the DNA binding and transcriptional activity of estrogen receptors (ERs), transcription factors which robustly and transiently regulate the expression of target genes. More broadly, estrogen signaling controls the ER cistrome, as well as the epigenome and the estrogen-regulated transcriptome. A host of deep sequencing-based genomic assays have provided novel insights into the mechanisms by which ERs regulate transcriptional responses. Estrogen-dependent transcriptional responses have been studied widely in breast cancer cells, primarily in the context of the ER alpha (ERα) isoform. These studies have revealed an intricate cross talk between the estrogen-ERα signaling pathway and other signaling pathways, impacting transcriptional programs and clinical outcomes in breast cancer. This chapter reviews the key features of ERα-regulated transcription and the current technological advances that have allowed for the careful dissection of these mechanisms.

Original languageEnglish (US)
Title of host publicationCancer Drug Discovery and Development
PublisherHumana Press Inc.
Pages95-127
Number of pages33
DOIs
StatePublished - 2019

Publication series

NameCancer Drug Discovery and Development
ISSN (Print)2196-9906
ISSN (Electronic)2196-9914

Keywords

  • Cistrome
  • Enhancer
  • Epigenome
  • Estrogen receptor
  • Transcriptome

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Drug Discovery

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    Vasquez, Y. M., & Kraus, W. L. (2019). The estrogen-regulated transcriptome: rapid, robust, extensive, and transient. In Cancer Drug Discovery and Development (pp. 95-127). (Cancer Drug Discovery and Development). Humana Press Inc.. https://doi.org/10.1007/978-3-319-99350-8_5