The eureka enzyme: The discovery of DNA polymerase

Research output: Contribution to journalReview article

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Abstract

The identification and partial purification by Arthur Kornberg and his colleagues in 1956 of an enzyme - DNA polymerase I of Escherichia coli - that catalysed the stable incorporation of deoxyribonucleotides into DNA in vitro came as a surprise. At the time, most scientists in the field believed that DNA synthesis was too complicated to be accurately reflected outside the living cell.

Original languageEnglish (US)
Pages (from-to)143-147
Number of pages5
JournalNature Reviews Molecular Cell Biology
Volume7
Issue number2
DOIs
StatePublished - Feb 1 2006

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ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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