The eureka enzyme: The discovery of DNA polymerase

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The identification and partial purification by Arthur Kornberg and his colleagues in 1956 of an enzyme - DNA polymerase I of Escherichia coli - that catalysed the stable incorporation of deoxyribonucleotides into DNA in vitro came as a surprise. At the time, most scientists in the field believed that DNA synthesis was too complicated to be accurately reflected outside the living cell.

Original languageEnglish (US)
Pages (from-to)143-147
Number of pages5
JournalNature Reviews Molecular Cell Biology
Volume7
Issue number2
DOIs
StatePublished - Feb 2006

Fingerprint

DNA-Directed DNA Polymerase
Deoxyribonucleotides
DNA Polymerase I
DNA
Enzymes
Escherichia coli
In Vitro Techniques

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

The eureka enzyme : The discovery of DNA polymerase. / Friedberg, Errol C.

In: Nature Reviews Molecular Cell Biology, Vol. 7, No. 2, 02.2006, p. 143-147.

Research output: Contribution to journalArticle

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