The Evolution of Angiogenic and Inflamed Tumors: The Renal Cancer Paradigm

Research output: Contribution to journalArticlepeer-review

Abstract

Gene expression analyses have identified subtypes of conventional renal cell carcinoma broadly distributed into angiogenic and proliferative/ immunogenic clades. Integration with genomic and functional experiments in animal models yields an evolutionary model. Evolutionary trajectories illustrate remarkable plasticity, particularly for a tumor that typically begins with inactivation of a single gene.

Original languageEnglish (US)
Pages (from-to)771-773
Number of pages3
JournalCancer Cell
Volume38
Issue number6
DOIs
StatePublished - Dec 14 2020

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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