Abstract
Delivery of cytoplasmic vesicles to discrete plasma-membrane domains is critical for establishing and maintaining cell polarity, neurite differentiation and regulated exocytosis. The exocyst is a multisubunit complex required for vectorial targeting of a subset of secretory vesicles. Mechanisms that regulate the activity of this complex in mammals are unknown. Here we show that Sec5, an integral component of the exocyst, is a direct target for activated Ral GTPases. Ral GTPases regulate targeting of basolateral proteins in epithelial cells, secretagogue-dependent exocytosis in neuroendocrine cells and assembly of exocyst complexes. These observations define Ral GTPases as critical regulators of vesicle trafficking.
Original language | English (US) |
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Pages (from-to) | 66-72 |
Number of pages | 7 |
Journal | Nature cell biology |
Volume | 4 |
Issue number | 1 |
DOIs | |
State | Published - 2002 |
ASJC Scopus subject areas
- Cell Biology