The exocyst is a Ral effector complex

Serge Moskalenko, Dale O. Henry, Carine Rosse, Gladys Mirey, Jacques H. Camonis, Michael A. White

Research output: Contribution to journalArticlepeer-review

338 Scopus citations

Abstract

Delivery of cytoplasmic vesicles to discrete plasma-membrane domains is critical for establishing and maintaining cell polarity, neurite differentiation and regulated exocytosis. The exocyst is a multisubunit complex required for vectorial targeting of a subset of secretory vesicles. Mechanisms that regulate the activity of this complex in mammals are unknown. Here we show that Sec5, an integral component of the exocyst, is a direct target for activated Ral GTPases. Ral GTPases regulate targeting of basolateral proteins in epithelial cells, secretagogue-dependent exocytosis in neuroendocrine cells and assembly of exocyst complexes. These observations define Ral GTPases as critical regulators of vesicle trafficking.

Original languageEnglish (US)
Pages (from-to)66-72
Number of pages7
JournalNature cell biology
Volume4
Issue number1
DOIs
StatePublished - 2002

ASJC Scopus subject areas

  • Cell Biology

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