The expanding role of BAP1 in clear cell renal cell carcinoma

Research output: Contribution to journalReview articlepeer-review

Abstract

Mutations drive renal cell carcinoma biology and tumor growth. The BRCA1-associated protein-1 (BAP1) gene is frequently mutated in clear cell renal cell carcinoma (ccRCC) and has emerged as a prognostic and putative predictive biomarker. In this review, we discuss the role of BAP1 as a signature event of a subtype of ccRCC marked by aggressiveness, inflammation, and possibly a heightened response to immunotherapy.

Original languageEnglish (US)
JournalHuman Pathology
DOIs
StateAccepted/In press - 2022

Keywords

  • BAP1
  • ccRCC
  • PBRM1
  • RCC

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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