The Extracellular Actin-Scavenger System and Actin Toxicity

William M. Lee, Robert M. Galbraith

Research output: Contribution to journalReview article

271 Scopus citations

Abstract

ACTIN is the most abundant protein in mammalian cells. Cell motility and change in the size and shape of cells depend on the ability of monomers of actin to polymerize to actin filaments. When actin is released from cells, however, its strong tendency to polymerize can become a liability, and the presence of filaments of actin in blood vessels can be fatal. Cell necrosis is associated with the release of actin in a variety of clinical situations, including hepatic necrosis, septic shock, the adult respiratory distress syndrome, and certain disorders of pregnancy. A newly described homeostatic mechanism, termed the actin-scavenger…

Original languageEnglish (US)
Pages (from-to)1335-1341
Number of pages7
JournalNew England Journal of Medicine
Volume326
Issue number20
DOIs
StatePublished - May 14 1992

ASJC Scopus subject areas

  • Medicine(all)

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