TY - JOUR
T1 - The Extracellular Actin-Scavenger System and Actin Toxicity
AU - Lee, William M.
AU - Galbraith, Robert M.
PY - 1992/5/14
Y1 - 1992/5/14
N2 - ACTIN is the most abundant protein in mammalian cells. Cell motility and change in the size and shape of cells depend on the ability of monomers of actin to polymerize to actin filaments. When actin is released from cells, however, its strong tendency to polymerize can become a liability, and the presence of filaments of actin in blood vessels can be fatal. Cell necrosis is associated with the release of actin in a variety of clinical situations, including hepatic necrosis, septic shock, the adult respiratory distress syndrome, and certain disorders of pregnancy. A newly described homeostatic mechanism, termed the actin-scavenger…
AB - ACTIN is the most abundant protein in mammalian cells. Cell motility and change in the size and shape of cells depend on the ability of monomers of actin to polymerize to actin filaments. When actin is released from cells, however, its strong tendency to polymerize can become a liability, and the presence of filaments of actin in blood vessels can be fatal. Cell necrosis is associated with the release of actin in a variety of clinical situations, including hepatic necrosis, septic shock, the adult respiratory distress syndrome, and certain disorders of pregnancy. A newly described homeostatic mechanism, termed the actin-scavenger…
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U2 - 10.1056/NEJM199205143262006
DO - 10.1056/NEJM199205143262006
M3 - Review article
C2 - 1314333
AN - SCOPUS:0026569069
SN - 0028-4793
VL - 326
SP - 1335
EP - 1341
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 20
ER -