The feasibility of conformal thermal therapy with transurethral ultrasound heating applicators and mr temperature feedback

Vanessa Choy, Kee Tang, Jeff Wachsmuth, Rajiv Chopra, Michael Bronskill

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Transurethral thermal therapy offers a minimally invasive alternative for the treatment of prostate diseases including benign prostate hyperplasia (BPH) and prostate cancer. Accurate heating of a targeted region of the gland can be achieved through the use of a rotating directional heating source incorporating planar ultrasound transducers, and the implementation of active temperature feedback along the beam direction during heating provided by magnetic resonance (MR) thermometry. The performance of this control method with practical spatial, temporal, and temperature resolution (such as angular alignment, spatial resolution, update rate for temperature feedback (imaging time), and the presence of noise) for thermal feedback using a clinical 1.5 T MR scanner was investigated in simulations. As expected, the control algorithm was most sensitive to the presence of noise, with noticeable degradation in its performance above ±2°C of temperature uncertainty. With respect to temporal resolution, acceptable performance was achieved at update rates of 5s or faster. The control algorithm was relatively insensitive to reduced spatial resolution due to the broad nature of the heating pattern produced by the heating applicator, this provides an opportunity to improve signal-to-noise ratio (SNR). The overall simulation results confirm that existing clinical 1.5T MR imagers are capable of providing adequate temperature feedback for transurethral thermal therapy without special pulse sequences or enhanced imaging hardware.

Original languageEnglish (US)
Title of host publicationAIP Conference Proceedings
Pages146-150
Number of pages5
Volume829
DOIs
Publication statusPublished - May 8 2006
EventTHERAPEUTIC ULTRASOUND: 5th International Symposium on Therapeutic Ultrasound - Boston, MA, United States
Duration: Oct 27 2005Oct 29 2005

Other

OtherTHERAPEUTIC ULTRASOUND: 5th International Symposium on Therapeutic Ultrasound
CountryUnited States
CityBoston, MA
Period10/27/0510/29/05

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Keywords

  • Control
  • MRI
  • Prostate
  • Thermal therapy
  • Thermometry
  • Ultrasound

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Choy, V., Tang, K., Wachsmuth, J., Chopra, R., & Bronskill, M. (2006). The feasibility of conformal thermal therapy with transurethral ultrasound heating applicators and mr temperature feedback. In AIP Conference Proceedings (Vol. 829, pp. 146-150) https://doi.org/10.1063/1.2205455