The feasibility of integrating elastography measurements into mri-guided transurethral ultrasound therapy

Arvin Arani, Yuexi Huang, Michael Bronskill, Rajiv Chopra

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

MRI-guided transurethral ultrasound therapy is being developed as a minimally invasive treatment for localized prostate cancer. The capability to identify target regions prior to therapy would provide an integrated diagnostic and therapeutic solution to the management of this disease. The objective of this project is to evaluate the feasibility of performing elastography using a transurethral actuator. Shear waves were generated in the prostate by vibrating the transurethral actuator longitudinally and resolving the tissue displacements with a 1.5 Tesla MRI. A piezoelectric actuator was used to vibrate the transurethral device with an amplitude of 32um at frequencies of 100 and 250Hz. GRE imaging sequences with displacement encoded along the direction of vibration were acquired transverse and parallel to the rod to visualize the dynamics of wave propagation. Experiments were performed in phantoms (8% gelatin) and in a canine model (n=5). Vibration was achieved in the MRI without significant loss of SNR in the images. The shear waves produced in the gel were cylindrical in nature, and extended along the length of the rod. Shear wave propagation in the canine prostate gland was observed at 100 and 250Hz, and shear modulus values agreed with previously published values.

Original languageEnglish (US)
Title of host publicationAIP Conference Proceedings
Pages265-269
Number of pages5
Volume1113
DOIs
Publication statusPublished - 2009
Event8th International Symposium on Therapeutic Ultrasound - Minneapolis, MN, United States
Duration: Sep 10 2008Sep 13 2008

Other

Other8th International Symposium on Therapeutic Ultrasound
CountryUnited States
CityMinneapolis, MN
Period9/10/089/13/08

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Keywords

  • Feasibility
  • MR elastography
  • MRI
  • Prostate Cancer
  • Prostate imaging
  • Transurethral

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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