The fine structure of nuclear changes in superior limbic keratoconjunctivitis

H. B. Collin, P. C. Donshik, S. A. Boruchoff, C. S. Foster, Harrison D Cavanagh

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Superior limbic keratoconjunctivitis (SLK) is a condition of unknown etiology. Histological signs include acanthosis, dyskeratosis, keratinization and balloon degeneration of the bulbar conjunctival epithelium. Ultrastructural examination of biopsy material from five eyes of patients with SLK shows numerous nuclear changes in the conjunctival epithelial cells. These include abnormal distribution and aggregation of nuclear chromatin, the presence of filaments within the nucleus, and dense accumulations of cytoplasmic filaments which surround the nucleus, resulting in 'strangulation' and the formation of multilobed nuclei or multinucleated cells. These changes do not appear to have been described previously in any cell type.

Original languageEnglish (US)
Pages (from-to)79-84
Number of pages6
JournalInvestigative Ophthalmology and Visual Science
Volume17
Issue number1
StatePublished - 1978

Fingerprint

Keratoconjunctivitis
Cytoskeleton
Chromatin
Epithelium
Epithelial Cells
Biopsy

ASJC Scopus subject areas

  • Ophthalmology

Cite this

The fine structure of nuclear changes in superior limbic keratoconjunctivitis. / Collin, H. B.; Donshik, P. C.; Boruchoff, S. A.; Foster, C. S.; Cavanagh, Harrison D.

In: Investigative Ophthalmology and Visual Science, Vol. 17, No. 1, 1978, p. 79-84.

Research output: Contribution to journalArticle

Collin, H. B. ; Donshik, P. C. ; Boruchoff, S. A. ; Foster, C. S. ; Cavanagh, Harrison D. / The fine structure of nuclear changes in superior limbic keratoconjunctivitis. In: Investigative Ophthalmology and Visual Science. 1978 ; Vol. 17, No. 1. pp. 79-84.
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