The finger domain of the human deubiquitinating enzyme HAUSP is a zinc ribbon

S. Sri Krishna, Nick V. Grishin

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Human deubiquitinating enzyme HAUSP is a cysteine protease that regulates the levels of the tumor suppressor protein p53. By comparative sequence and structural analysis, we show that the previously uncharacterized finger domain insert to the catalytic core of HAUSP is a zinc ribbon that has lost its zinc-binding ability.

Original languageEnglish (US)
Pages (from-to)1046-1049
Number of pages4
JournalCell Cycle
Volume3
Issue number8
StatePublished - Aug 2004

Fingerprint

Fingers
Zinc
Tumor Suppressor Protein p53
Cysteine Proteases
Enzymes
Structural analysis
Sequence Analysis
Catalytic Domain
Deubiquitinating Enzymes

Keywords

  • DUB
  • MDM2
  • p53
  • Rubredoxin
  • Ubiquitin

ASJC Scopus subject areas

  • Cell Biology
  • Biochemistry
  • Molecular Biology

Cite this

The finger domain of the human deubiquitinating enzyme HAUSP is a zinc ribbon. / Krishna, S. Sri; Grishin, Nick V.

In: Cell Cycle, Vol. 3, No. 8, 08.2004, p. 1046-1049.

Research output: Contribution to journalArticle

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