The finger domain of the human deubiquitinating enzyme HAUSP is a zinc ribbon

S. Sri Krishna; Nick V. Grishin

doi:10.4161/cc.3.8.1017

The finger domain of the human deubiquitinating enzyme HAUSP is a zinc ribbon

S. Sri Krishna, Nick V. Grishin

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Human deubiquitinating enzyme HAUSP is a cysteine protease that regulates the levels of the tumor suppressor protein p53. By comparative sequence and structural analysis, we show that the previously uncharacterized finger domain insert to the catalytic core of HAUSP is a zinc ribbon that has lost its zinc-binding ability.

Original language	English (US)
Pages (from-to)	1044-1047
Number of pages	4
Journal	Cell Cycle
Volume	3
Issue number	8
DOIs	https://doi.org/10.4161/cc.3.8.1017
State	Published - Aug 2004

Keywords

DUB
MDM2
Rubredoxin
Ubiquitin
p53

ASJC Scopus subject areas

Molecular Biology
Developmental Biology
Cell Biology

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10.4161/cc.3.8.1017

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title = "The finger domain of the human deubiquitinating enzyme HAUSP is a zinc ribbon",

abstract = "Human deubiquitinating enzyme HAUSP is a cysteine protease that regulates the levels of the tumor suppressor protein p53. By comparative sequence and structural analysis, we show that the previously uncharacterized finger domain insert to the catalytic core of HAUSP is a zinc ribbon that has lost its zinc-binding ability.",

keywords = "DUB, MDM2, Rubredoxin, Ubiquitin, p53",

author = "Krishna, {S. Sri} and Grishin, {Nick V.}",

note = "Funding Information: This work was supported by NIH grant GM67165 to N.V.G.",

year = "2004",

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AU - Grishin, Nick V.

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N2 - Human deubiquitinating enzyme HAUSP is a cysteine protease that regulates the levels of the tumor suppressor protein p53. By comparative sequence and structural analysis, we show that the previously uncharacterized finger domain insert to the catalytic core of HAUSP is a zinc ribbon that has lost its zinc-binding ability.

AB - Human deubiquitinating enzyme HAUSP is a cysteine protease that regulates the levels of the tumor suppressor protein p53. By comparative sequence and structural analysis, we show that the previously uncharacterized finger domain insert to the catalytic core of HAUSP is a zinc ribbon that has lost its zinc-binding ability.

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KW - Rubredoxin

KW - Ubiquitin

KW - p53

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The finger domain of the human deubiquitinating enzyme HAUSP is a zinc ribbon

Abstract

Keywords

ASJC Scopus subject areas

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