The finger domain of the human deubiquitinating enzyme HAUSP is a zinc ribbon

S. Sri Krishna, Nick V. Grishin

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Human deubiquitinating enzyme HAUSP is a cysteine protease that regulates the levels of the tumor suppressor protein p53. By comparative sequence and structural analysis, we show that the previously uncharacterized finger domain insert to the catalytic core of HAUSP is a zinc ribbon that has lost its zinc-binding ability.

Original languageEnglish (US)
Pages (from-to)1044-1047
Number of pages4
JournalCell Cycle
Volume3
Issue number8
DOIs
StatePublished - Aug 2004

Keywords

  • DUB
  • MDM2
  • Rubredoxin
  • Ubiquitin
  • p53

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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