The first case of Philadelphia chromosome-negative acute promyelocytic leukemia following imatinib for chronic myelogenous leukemia

Jad J. Wakim, Carlos A. Tirado, Jonathan Dowell, Weina Chen

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

In chronic myelogenous leukemia, chromosomal abnormalities in Philadelphia-negative cells are rare and usually transient, but can infrequently lead to myelodysplastic syndrome and/or acute myeloid leukemia. We report an 82-ear-old patient with an 11-year history of chronic myelogenous leukemia, in complete cytogenetic response, who developed Philadelphia-negative t(15;17)/PMLRARA acute promyelocytic leukemia. This isolated case reaffirms several important clinicopathologic and biologic aspects of chronic myelogenous leukemia, and sheds a unique light on its Philadelphia-negative hematopoiesis. It also underlines the importance of continued cytogenetic monitoring of patients in complete cytogenetic response for the emergence of new chromosomal abnormalities.

Original languageEnglish (US)
Pages (from-to)124-127
Number of pages4
JournalCancer Genetics
Volume205
Issue number3
DOIs
StatePublished - Mar 1 2012

Keywords

  • Acute promyelocytic leukemia
  • Chromosomal abnormalities
  • Chronic myeloid leukemia
  • Imatinib
  • Philadelphia chromosome-negative

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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