Abstract
In chronic myelogenous leukemia, chromosomal abnormalities in Philadelphia-negative cells are rare and usually transient, but can infrequently lead to myelodysplastic syndrome and/or acute myeloid leukemia. We report an 82-ear-old patient with an 11-year history of chronic myelogenous leukemia, in complete cytogenetic response, who developed Philadelphia-negative t(15;17)/PMLRARA acute promyelocytic leukemia. This isolated case reaffirms several important clinicopathologic and biologic aspects of chronic myelogenous leukemia, and sheds a unique light on its Philadelphia-negative hematopoiesis. It also underlines the importance of continued cytogenetic monitoring of patients in complete cytogenetic response for the emergence of new chromosomal abnormalities.
Original language | English (US) |
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Pages (from-to) | 124-127 |
Number of pages | 4 |
Journal | Cancer Genetics |
Volume | 205 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2012 |
Keywords
- Acute promyelocytic leukemia
- Chromosomal abnormalities
- Chronic myeloid leukemia
- Imatinib
- Philadelphia chromosome-negative
ASJC Scopus subject areas
- Molecular Biology
- Genetics
- Cancer Research