The Flavone Baicalein and Its Use in Gastrointestinal Disease

Yangchun Xie, Rui Kang, Daolin Tang

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Traditional Chinese medicine (TCM), which involves the use of herbal medicinal products and supplements, has been practiced for thousands of years in China and other Asian countries. Baicalein (5,6,7-trihydroxyflavone), the major bioactive flavone in Scutellaria baicalensis Georgi (Huang Qin in Chinese), is one of the most commonly used herbal products in TCM. Baicalein and its active metabolite baicalin exhibit a range of chemical activities in the regulation of oxidative stress, inflammation response, cell differentiation, and cell death. Because of these properties, baicalein is used widely for the prevention and treatment of various human diseases including cancers, autoimmune disorders, neurological disorders, and inflammatory diseases. The current chapter summarizes the pharmacological effects of baicalein and its use in gastrointestinal disease.

Original languageEnglish (US)
Title of host publicationDietary Interventions in Liver Disease
Subtitle of host publicationFoods, Nutrients, and Dietary Supplements
PublisherElsevier
Pages145-155
Number of pages11
ISBN (Electronic)9780128144671
ISBN (Print)9780128144664
DOIs
StatePublished - Jan 16 2019
Externally publishedYes

Keywords

  • Baicalein
  • Cancer
  • Gastrointestinal disease
  • Inflammation
  • Traditional Chinese medicine

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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