The formation of 5α androstane 3α,17β diol by dog prostate

G. H. Jacobi, J. D. Wilson

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

The 3 keto reduction of [1,2 3H] dihydrotestosterone to 3α and 3β androstanediol has been assessed in homogenates of 31 dog prostates that varied in size from < 1 to > 15 g. The formation of both androstanediols was demonstrable in microsomes and cytosol, and both NADH and NADPH were effective cofactors for the two reactions. The formation of 3β androstanediol per unit weight of prostate or per mg protein did not show a clear cut relation with the size of the gland, but 3α androstanediol formation per mg microsomal protein increased as a linear function with size so that the rates were on an average 10 fold greater in prostates > 15 g than in those < 5 g in weight.

Original languageEnglish (US)
Pages (from-to)602-610
Number of pages9
JournalEndocrinology
Volume99
Issue number2
StatePublished - 1976

Fingerprint

Androstane-3,17-diol
Prostate
Dogs
Weights and Measures
Dihydrotestosterone
Microsomes
NADP
NAD
Cytosol
Proteins

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Jacobi, G. H., & Wilson, J. D. (1976). The formation of 5α androstane 3α,17β diol by dog prostate. Endocrinology, 99(2), 602-610.

The formation of 5α androstane 3α,17β diol by dog prostate. / Jacobi, G. H.; Wilson, J. D.

In: Endocrinology, Vol. 99, No. 2, 1976, p. 602-610.

Research output: Contribution to journalArticle

Jacobi, GH & Wilson, JD 1976, 'The formation of 5α androstane 3α,17β diol by dog prostate', Endocrinology, vol. 99, no. 2, pp. 602-610.
Jacobi, G. H. ; Wilson, J. D. / The formation of 5α androstane 3α,17β diol by dog prostate. In: Endocrinology. 1976 ; Vol. 99, No. 2. pp. 602-610.
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