Abstract
Recognition of the microbial world is mediated chiefly by a small group of immune receptors that activate a characteristic host inflammatory response, the innate immune response. Known as the Toll-like receptors (TLRs), these molecules are represented among most metazoans. In mammals, forward genetic analysis of the lipopolysaccharide (LPS) response led to the identification of TLR4 as the LPS receptor. Through a combination of forward and reverse genetic studies, a relatively detailed understanding of the functions of mammalian TLRs has now been achieved. As discussed here, mutagenesis has revealed proteins that participate in TLR signaling pathways, and informed our understanding of the subtleties of these molecules' structure and function.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3-26 |
| Number of pages | 24 |
| Journal | Current Topics in Microbiology and Immunology |
| Volume | 321 |
| DOIs | |
| State | Published - 2008 |
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ASJC Scopus subject areas
- Immunology and Allergy
- Microbiology (medical)
- Immunology
- Microbiology
- Immunology and Microbiology(all)
Cite this
The forward genetic dissection of afferent innate immunity. / Beutler, B.; Moresco, E. M Y.
In: Current Topics in Microbiology and Immunology, Vol. 321, 2008, p. 3-26.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The forward genetic dissection of afferent innate immunity
AU - Beutler, B.
AU - Moresco, E. M Y
PY - 2008
Y1 - 2008
N2 - Recognition of the microbial world is mediated chiefly by a small group of immune receptors that activate a characteristic host inflammatory response, the innate immune response. Known as the Toll-like receptors (TLRs), these molecules are represented among most metazoans. In mammals, forward genetic analysis of the lipopolysaccharide (LPS) response led to the identification of TLR4 as the LPS receptor. Through a combination of forward and reverse genetic studies, a relatively detailed understanding of the functions of mammalian TLRs has now been achieved. As discussed here, mutagenesis has revealed proteins that participate in TLR signaling pathways, and informed our understanding of the subtleties of these molecules' structure and function.
AB - Recognition of the microbial world is mediated chiefly by a small group of immune receptors that activate a characteristic host inflammatory response, the innate immune response. Known as the Toll-like receptors (TLRs), these molecules are represented among most metazoans. In mammals, forward genetic analysis of the lipopolysaccharide (LPS) response led to the identification of TLR4 as the LPS receptor. Through a combination of forward and reverse genetic studies, a relatively detailed understanding of the functions of mammalian TLRs has now been achieved. As discussed here, mutagenesis has revealed proteins that participate in TLR signaling pathways, and informed our understanding of the subtleties of these molecules' structure and function.
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UR - http://www.scopus.com/inward/citedby.url?scp=51149097174&partnerID=8YFLogxK
U2 - 10.1007/978-3-540-75203-5_1
DO - 10.1007/978-3-540-75203-5_1
M3 - Article
C2 - 18727485
AN - SCOPUS:51149097174
VL - 321
SP - 3
EP - 26
JO - Current Topics in Microbiology and Immunology
JF - Current Topics in Microbiology and Immunology
SN - 0070-217X
ER -