The functional magnetic resonance imaging-based verbal fluency test in obsessive-compulsive disorder

Fu L. Woon, Mark D. Allen, Chris H. Miller, Dawson W. Hedges

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Clinical use of functional magnetic resonance imaging (fMRI) in obsessive-compulsive disorder (OCD) is limited by a relative absence of fMRI task development, standardization, and normative performance databases. We investigated the fMRI-based verbal fluency test (f-VFT) by quantitatively evaluating brain activation patterns in OCD participants (8 females and 4 males) compared with a normative database (16 females and 16 males). At the group level, OCD participants and references had highly similar activation in left-hemisphere language regions, including the precentral/premotor cortex, thalamus, basal ganglia, and inferior frontal gyrus/frontal operculum. At the interindividual level, however, the OCD group had highly variable activation patterns in the dorsal and ventral regions of the pre-supplementary motor area (pre-SMA) that may correspond with differences in demographic and clinical variables. Further, there were significant correlations in the OCD participants between pre-SMA dorsal and ventral activation and between dorsal pre-SMA activation and perfectionism. Our findings suggest considerable functional anatomical overlap in left-hemisphere language regions between OCD participants and references but significantly higher pre-SMA interindividual variability in OCD compared to the reference group that may be relevant in clinical fMRI application and the theoretical understanding of OCD.

Original languageEnglish (US)
Pages (from-to)424-440
Number of pages17
JournalNeurocase
Volume18
Issue number5
DOIs
StatePublished - Oct 2012

Fingerprint

Obsessive-Compulsive Disorder
Magnetic Resonance Imaging
Motor Cortex
Language
Databases
Functional Magnetic Resonance Imaging
Verbal Fluency
Obsessive-compulsive Disorder
Basal Ganglia
Prefrontal Cortex
Thalamus
Demography
Activation
Brain

Keywords

  • Controlled oral word association test
  • fMRI
  • Functional magnetic resonance imaging
  • Functional neuroimaging
  • Individual differences
  • Neuropsychology
  • Obsessive-compulsive disorder
  • Pre-supplementary motor area
  • Verbal fluency

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

Cite this

The functional magnetic resonance imaging-based verbal fluency test in obsessive-compulsive disorder. / Woon, Fu L.; Allen, Mark D.; Miller, Chris H.; Hedges, Dawson W.

In: Neurocase, Vol. 18, No. 5, 10.2012, p. 424-440.

Research output: Contribution to journalArticle

Woon, Fu L. ; Allen, Mark D. ; Miller, Chris H. ; Hedges, Dawson W. / The functional magnetic resonance imaging-based verbal fluency test in obsessive-compulsive disorder. In: Neurocase. 2012 ; Vol. 18, No. 5. pp. 424-440.
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