The gene for the human putative apoE receptor is on chromosome 12 in the segment q13-14

Ola Myklebost; Kristina Arheden; Sissel Rogne; Ad Geurts van Kessel; Nils Mandahl; Joachim Herz; Keith Stanley; Sverre Heim; Felix Mitelman

doi:10.1016/0888-7543(89)90087-6

The gene for the human putative apoE receptor is on chromosome 12 in the segment q13-14

Ola Myklebost, Kristina Arheden, Sissel Rogne, Ad Geurts van Kessel, Nils Mandahl, Joachim Herz, Keith Stanley, Sverre Heim, Felix Mitelman

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Abstract

We have previously described the cDNA coding for a new lipoprotein receptor that contains domains closely related to the ligand-binding domain of the LDL receptor. We have now investigated the localization of the gene for this new receptor by hybridization of the cDNA to panels of rodent cells containing subsets of human chromosomes and by in situ hybridization of the cDNA to chromosomes. The gene maps to 12q13-14, a known hot spot for chromosomal rearrangements in human neoplasia. Of particular interest is the frequent involvement of the 12q13-14 segment in clonal abnormalities in lipomas and myxoid liposarcomas, and it is possible that LRP may play a role in the pathogenesis of such tumors.

Original language	English (US)
Pages (from-to)	65-69
Number of pages	5
Journal	Genomics
Volume	5
Issue number	1
DOIs	https://doi.org/10.1016/0888-7543(89)90087-6
State	Published - Jul 1989

ASJC Scopus subject areas

Genetics

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10.1016/0888-7543(89)90087-6

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title = "The gene for the human putative apoE receptor is on chromosome 12 in the segment q13-14",

abstract = "We have previously described the cDNA coding for a new lipoprotein receptor that contains domains closely related to the ligand-binding domain of the LDL receptor. We have now investigated the localization of the gene for this new receptor by hybridization of the cDNA to panels of rodent cells containing subsets of human chromosomes and by in situ hybridization of the cDNA to chromosomes. The gene maps to 12q13-14, a known hot spot for chromosomal rearrangements in human neoplasia. Of particular interest is the frequent involvement of the 12q13-14 segment in clonal abnormalities in lipomas and myxoid liposarcomas, and it is possible that LRP may play a role in the pathogenesis of such tumors.",

author = "Ola Myklebost and Kristina Arheden and Sissel Rogne and Kessel, {Ad Geurts van} and Nils Mandahl and Joachim Herz and Keith Stanley and Sverre Heim and Felix Mitelman",

note = "Funding Information: This work was supported by the Norwegian, Swedish, and Dutch (Koningin Wilhelmina Fonds) Cancer Societies, the Swedish Work Environment Fund, and the JAP Foundation for Medical Research.",

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T1 - The gene for the human putative apoE receptor is on chromosome 12 in the segment q13-14

AU - Myklebost, Ola

AU - Arheden, Kristina

AU - Rogne, Sissel

AU - Kessel, Ad Geurts van

AU - Mandahl, Nils

AU - Herz, Joachim

AU - Stanley, Keith

AU - Heim, Sverre

AU - Mitelman, Felix

N1 - Funding Information: This work was supported by the Norwegian, Swedish, and Dutch (Koningin Wilhelmina Fonds) Cancer Societies, the Swedish Work Environment Fund, and the JAP Foundation for Medical Research.

PY - 1989/7

Y1 - 1989/7

N2 - We have previously described the cDNA coding for a new lipoprotein receptor that contains domains closely related to the ligand-binding domain of the LDL receptor. We have now investigated the localization of the gene for this new receptor by hybridization of the cDNA to panels of rodent cells containing subsets of human chromosomes and by in situ hybridization of the cDNA to chromosomes. The gene maps to 12q13-14, a known hot spot for chromosomal rearrangements in human neoplasia. Of particular interest is the frequent involvement of the 12q13-14 segment in clonal abnormalities in lipomas and myxoid liposarcomas, and it is possible that LRP may play a role in the pathogenesis of such tumors.

AB - We have previously described the cDNA coding for a new lipoprotein receptor that contains domains closely related to the ligand-binding domain of the LDL receptor. We have now investigated the localization of the gene for this new receptor by hybridization of the cDNA to panels of rodent cells containing subsets of human chromosomes and by in situ hybridization of the cDNA to chromosomes. The gene maps to 12q13-14, a known hot spot for chromosomal rearrangements in human neoplasia. Of particular interest is the frequent involvement of the 12q13-14 segment in clonal abnormalities in lipomas and myxoid liposarcomas, and it is possible that LRP may play a role in the pathogenesis of such tumors.

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The gene for the human putative apoE receptor is on chromosome 12 in the segment q13-14

Abstract

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