The generalized pattern of neuropsychological deficits in outpatients with chronic schizophrenia with heterogeneous Wisconsin Card Sorting Test results

David L. Braff, Robert Heaton, Julie Kuck, Munro Cullum, John Moranville, Igor Grant, Sidney Zisook

Research output: Contribution to journalArticle

335 Citations (Scopus)

Abstract

• Forty schizophrenic outpatients and 40 normal subjects were assessed using extensive clinical (eg, Brief Psychiatric Rating Scale, Scale for the Assessment of Negative Symptoms and Scale for the Assessment of Positive Symptoms) and neuropsychological (extended Halstead-Reitan Battery) measures. The schizophrenic patients had multiple neuropsychological deficits on tests of complex conceptual mooning, psychomotor speed, new learning and incidental memory, and both motor and sensory-perceptual abilities. Neuropsychological impairment correlated more strongly with negative than positive symptoms. Overall, the schizophrenic outpatients showed relatively modest increases in the number of perseverative responses on the Wisconsin Card Sorting Test of abstraction flexibility. A subgroup of these schizophrenic patients seemed to be particularly impaired on the Wisconsin Card Sorting Test. This pattern of results, in conjunction with previous studies, supports the idea that, while some schizophrenic patients may have fixed, frontally based dysfunctions, these dysfunctions may be most prominent, and even fixed, in deteriorated, kraepelinian patients. These data provide evidence for diffuse and far-reaching deficits in a majority of outpatients with chronic schizophrenia.

Original languageEnglish (US)
Pages (from-to)891-898
Number of pages8
JournalArchives of General Psychiatry
Volume48
Issue number10
StatePublished - 1991

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Schizophrenia
Outpatients
Brief Psychiatric Rating Scale
Aptitude
Symptom Assessment
Learning

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

The generalized pattern of neuropsychological deficits in outpatients with chronic schizophrenia with heterogeneous Wisconsin Card Sorting Test results. / Braff, David L.; Heaton, Robert; Kuck, Julie; Cullum, Munro; Moranville, John; Grant, Igor; Zisook, Sidney.

In: Archives of General Psychiatry, Vol. 48, No. 10, 1991, p. 891-898.

Research output: Contribution to journalArticle

Braff, David L. ; Heaton, Robert ; Kuck, Julie ; Cullum, Munro ; Moranville, John ; Grant, Igor ; Zisook, Sidney. / The generalized pattern of neuropsychological deficits in outpatients with chronic schizophrenia with heterogeneous Wisconsin Card Sorting Test results. In: Archives of General Psychiatry. 1991 ; Vol. 48, No. 10. pp. 891-898.
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