The generation of immunotoxins using chimeric anti-CD22 antibodies containing mutations which alter their serum half-life

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Abstract

Murine and chimeric RFB4 (anti-human CD22) monoclonal antibodies (MAbs) with mutations in their Fc portions were conjugated to recombinant ricin toxin A chain to generate immunotoxins. The resulting immunotoxins (ITs) constructed with chimeric RFB4 MAbs were designed to have longer or shorter half-lives but similar binding and cytotoxic properties. These ITs can now be evaluated in vivo for improved therapeutic indices. The characteristics of these ITs are the subject of this report.

Original languageEnglish (US)
Pages (from-to)1279-1290
Number of pages12
JournalInternational Immunopharmacology
Volume5
Issue number7-8
DOIs
Publication statusPublished - Jul 2005

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Keywords

  • Anti-CD22
  • Fc mutations
  • FcRn
  • Ricin A chain

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

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