Abstract
Murine and chimeric RFB4 (anti-human CD22) monoclonal antibodies (MAbs) with mutations in their Fc portions were conjugated to recombinant ricin toxin A chain to generate immunotoxins. The resulting immunotoxins (ITs) constructed with chimeric RFB4 MAbs were designed to have longer or shorter half-lives but similar binding and cytotoxic properties. These ITs can now be evaluated in vivo for improved therapeutic indices. The characteristics of these ITs are the subject of this report.
Original language | English (US) |
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Pages (from-to) | 1279-1290 |
Number of pages | 12 |
Journal | International Immunopharmacology |
Volume | 5 |
Issue number | 7-8 |
DOIs | |
State | Published - Jul 1 2005 |
Keywords
- Anti-CD22
- Fc mutations
- FcRn
- Ricin A chain
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Pharmacology