The Genetics of Behavioral Alcohol Responses in Drosophila

Research output: Book/ReportBook

37 Citations (Scopus)

Abstract

Drosophila melanogaster is commonly found near rotting or fermenting fruit, reflected in its name pomace, or vinegar fly. In such environments, flies often encounter significant levels of ethanol. Three observations have made Drosophila a very promising model organism to understand the genetic contributions to the behavioral responses to alcohol. First, similar to higher vertebrates, flies show hyperactivation upon exposure to a low to medium dose of alcohol, while high doses can lead to sedation. In addition, when given a choice, flies will actually prefer alcohol-containing food over regular food. Second, the genes and biochemical pathways implicated in controlling these behavioral responses in flies are also participating in determining alcohol responses, and drinking behavior in mammals. Third, the fact that flies have been studied genetically for over one hundred years means that an exceptional repertoire of genetic tools are at our disposal. Here, we will review some of these tools and experimental approaches, survey the methods for, and measures after Drosophila ethanol exposure, and discuss the different molecular components and functional pathways involved in these behavioral responses to alcohol.

Original languageEnglish (US)
PublisherUnknown Publisher
Number of pages27
Volume91
EditionC
DOIs
StatePublished - 2010

Publication series

NameInternational Review of Neurobiology
No.C
Volume91
ISSN (Print)00747742

Fingerprint

Behavioral Genetics
Diptera
Drosophila
Alcohols
Ethanol
Food
Drinking Behavior
Drosophila melanogaster
Acetic Acid
Alcohol Drinking
Names
Vertebrates
Mammals
Fruit
Genes

Keywords

  • Abuse
  • Alcohol
  • Behavior
  • Drosophila
  • Genetics

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

Rodan, A. R., & Rothenfluh, A. (2010). The Genetics of Behavioral Alcohol Responses in Drosophila. (C ed.) (International Review of Neurobiology; Vol. 91, No. C). Unknown Publisher. https://doi.org/10.1016/S0074-7742(10)91002-7

The Genetics of Behavioral Alcohol Responses in Drosophila. / Rodan, Aylin R.; Rothenfluh, Adrian.

C ed. Unknown Publisher, 2010. 27 p. (International Review of Neurobiology; Vol. 91, No. C).

Research output: Book/ReportBook

Rodan, AR & Rothenfluh, A 2010, The Genetics of Behavioral Alcohol Responses in Drosophila. International Review of Neurobiology, no. C, vol. 91, vol. 91, C edn, Unknown Publisher. https://doi.org/10.1016/S0074-7742(10)91002-7
Rodan AR, Rothenfluh A. The Genetics of Behavioral Alcohol Responses in Drosophila. C ed. Unknown Publisher, 2010. 27 p. (International Review of Neurobiology; C). https://doi.org/10.1016/S0074-7742(10)91002-7
Rodan, Aylin R. ; Rothenfluh, Adrian. / The Genetics of Behavioral Alcohol Responses in Drosophila. C ed. Unknown Publisher, 2010. 27 p. (International Review of Neurobiology; C).
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