The genetics of essential metal homeostasis during development

Taiho Kambe, Benjamin P. Weaver, Glen K. Andrews

Research output: Contribution to journalReview article

96 Scopus citations

Abstract

The essential metals copper, zinc, and iron play key roles in embryonic, fetal, and postnatal development in higher eukaryotes. Recent advances in our understanding of the molecules involved in the intricate control of the homeostasis of these metals and the availability of natural mutations and targeted mutations in many of the genes involved have allowed for elucidation of the diverse roles of these metals during development. Evidence suggests that the ability of the embryo to control the homeostasis of these metals becomes essential at the blastocyst stage and during early morphogenesis. However, these metals play unique roles throughout development and exert pleiotropic, metal-specific, and often cell-specific effects on morphogenesis, growth, and differentiation. Herein, we briefly review the major players known to be involved in the homeostasis of each of these essential metals and their known roles in development.

Original languageEnglish (US)
Pages (from-to)214-228
Number of pages15
JournalGenesis
Volume46
Issue number4
DOIs
StatePublished - Apr 1 2008

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Keywords

  • Copper
  • Development
  • Genetics
  • Homeostasis
  • Iron
  • Knockout mice
  • Review
  • Zinc

ASJC Scopus subject areas

  • Genetics
  • Endocrinology
  • Cell Biology

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