The Genetics of Mouse Models of Systemic Lupus

Srividya Subramanian, Edward K. Wakeland

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The prototype of systemic autoimmune disorders, systemic lupus erythematosus, is characterized by a loss in immunological tolerance to a variety of ubiquitous self-antigens, such as chromatin, double-stranded DNA, ribonucleoproteins, and complement. These immune irregularities are postulated to be a consequence of changes in the activation thresholds and functions of immune cells, variations in the cytokine milieu produced, alterations in the clearance of apoptotic and necrotic debris by phagocytotic cells, and modulations in antigen presentation capacities. The lupus model provides a framework to interpret the genetic interactions that progressively increase disease pathogenesis in mouse model systems. The remaining questions focus on the identification of the specific disease alleles and the characterization of the molecular mechanisms responsible for driving disease. Although identification of the disease-causing genes still remains a challenge, advances in technology and the persistent efforts of many investigators are beginning to break down the major obstacles of positional cloning strategies. As disease alleles are identified in mouse models of systemic autoimmunity, this new information will undoubtedly increase the understanding of disease progression in humans.

Original languageEnglish (US)
Title of host publicationThe Mouse in Biomedical Research
PublisherElsevier Inc.
Pages243-259
Number of pages17
Volume4
ISBN (Print)9780123694546
DOIs
Publication statusPublished - 2007

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ASJC Scopus subject areas

  • veterinary(all)

Cite this

Subramanian, S., & Wakeland, E. K. (2007). The Genetics of Mouse Models of Systemic Lupus. In The Mouse in Biomedical Research (Vol. 4, pp. 243-259). Elsevier Inc.. https://doi.org/10.1016/B978-012369454-6/50089-3