The Genitourinary Pathology Society Update on Classification of Variant Histologies, T1 Substaging, Molecular Taxonomy, and Immunotherapy and PD-L1 Testing Implications of Urothelial Cancers

Eva Compérat, Mahul B. Amin, Jonathan I. Epstein, Donna E. Hansel, Gladell Paner, Hikmat Al-Ahmadie, Larry True, DIlek Bayder, Trinity Bivalacqua, Fadi Brimo, Liang Cheng, John Cheville, Guido Dalbagni, Sara Falzarano, Jennifer Gordetsky, Charles Guo, Sounak Gupta, Ondrej Hes, Gopa Iyer, Seema KaushalLakshmi Kunju, Cristina Magi-Galluzzi, Andres Matoso, Jesse McKenney, George J. Netto, Adeboye O. Osunkoya, Chin Chen Pan, Kristina Pivovarcikova, Maria R. Raspollini, Henning Reis, Jonathan Rosenberg, Morgan Roupret, Rajal B. Shah, Shahrokh F. Shariat, Kiril Trpkov, Veronika Weyerer, Ming Zhou, Victor Reuter

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

The Genitourinary Pathology Society (GUPS) undertook a critical review of the recent advances in bladder cancer focusing on important topics of high interest for the practicing surgical pathologist and urologist. This review represents the second of 2 manuscripts ensuing from this effort. Herein, we address the effective reporting of bladder cancer, focusing particularly on newly published data since the last 2016 World Health Organization (WHO) classification. In addition, this review focuses on the importance of reporting bladder cancer with divergent differentiation and variant (subtypes of urothelial carcinoma) histologies and the potential impact on patient care. We provide new recommendations for reporting pT1 staging in diagnostic pathology. Furthermore, we explore molecular evolution and classification, emphasizing aspects that impact the understanding of important concepts relevant to reporting and management of patients.

Original languageEnglish (US)
Pages (from-to)196-208
Number of pages13
JournalAdvances in anatomic pathology
Volume28
Issue number4
DOIs
StatePublished - Jul 2021
Externally publishedYes

Keywords

  • WHO classification
  • bladder cancer
  • immunotherapy
  • molecular classification of bladder cancer
  • pTNM
  • pathology
  • stage
  • subtypes
  • urothelial carcinoma
  • variant histology

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

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