The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats

Joel D. Taurog, James A. Richardson, JoAnne T. Croft, William A. Simmons, Ming Zhou, José Luis Fernández-Sueiro, Edward Balish, Robert E. Hammer

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Abstract

A number of inflammatory disease states occur with greatly increased frequency in individuals inheriting the human major histocompatibility complex class I allele HLA-B27. In a minority of cases, namely those with B27-associated reactive arthritis, there is good evidence that the disease state is triggered by infection with an enteric or genitourinary bacterial pathogen. For the majority of B27-associated disease, no definite pathogenetic role for bacteria has been established. However, in these latter cases intestinal inflammation can often be demonstrated, and it sometimes occupies a major part of the clinical picture. Rats transgenic for B27 are known to develop a disorder resembling B27-associated human disease, with prominent intestinal, joint, skin, and male genital inflammatory lesions. We report here that B27 transgenic rats raised in a germfree environment do not develop inflammatory intestinal or peripheral joint disease, whereas the skin and genital inflammatory lesions are unaffected by the germfree state. These findings support the concept that gut and joint inflammation are pathogenetically closely related, and they provide direct evidence that the commensal gut flora play an important role in the pathogenesis of B27- associated gut and joint inflammation.

Original languageEnglish (US)
Pages (from-to)2359-2364
Number of pages6
JournalJournal of Experimental Medicine
Volume180
Issue number6
DOIs
StatePublished - Dec 1 1994

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Transgenic Rats
HLA-B27 Antigen
Joint Diseases
Joints
Inflammation
Reactive Arthritis
Skin
Major Histocompatibility Complex
Alleles
Bacteria
Infection

ASJC Scopus subject areas

  • Immunology

Cite this

Taurog, J. D., Richardson, J. A., Croft, J. T., Simmons, W. A., Zhou, M., Fernández-Sueiro, J. L., ... Hammer, R. E. (1994). The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats. Journal of Experimental Medicine, 180(6), 2359-2364. https://doi.org/10.1084/jem.180.6.2359

The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats. / Taurog, Joel D.; Richardson, James A.; Croft, JoAnne T.; Simmons, William A.; Zhou, Ming; Fernández-Sueiro, José Luis; Balish, Edward; Hammer, Robert E.

In: Journal of Experimental Medicine, Vol. 180, No. 6, 01.12.1994, p. 2359-2364.

Research output: Contribution to journalArticle

Taurog, JD, Richardson, JA, Croft, JT, Simmons, WA, Zhou, M, Fernández-Sueiro, JL, Balish, E & Hammer, RE 1994, 'The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats', Journal of Experimental Medicine, vol. 180, no. 6, pp. 2359-2364. https://doi.org/10.1084/jem.180.6.2359
Taurog, Joel D. ; Richardson, James A. ; Croft, JoAnne T. ; Simmons, William A. ; Zhou, Ming ; Fernández-Sueiro, José Luis ; Balish, Edward ; Hammer, Robert E. / The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats. In: Journal of Experimental Medicine. 1994 ; Vol. 180, No. 6. pp. 2359-2364.
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