The graft-versus-lymphoma effect: Clinical review and future opportunities

B. W. Butcher, Robert H. Collins

Research output: Contribution to journalReview article

28 Scopus citations

Abstract

Numerous lines of preclinical and clinical evidence support the existence of a graft-versus-leukemia effect, but less evidence supporting a comparable graft-versus-lymphoma effect exists. We review here current clinical data addressing the graft-versus-lymphoma effect, including comparisons of autologous, syngeneic, and allogeneic transplantation; responses to immunomodulation; and responses to nonmyeloablative stem cell transplantation. Despite several limitations of the data, we believe that there is sufficient evidence suggesting a significant graft-versus-lymphoma effect. In addition, we discuss approaches for clinical management of lymphoma patients, opportunities for mechanistic studies afforded by donor leukocyte infusions and nonmyeloablative transplantation, and suggestions for clinical studies to further define the magnitude and applicability of the graft-versus-lymphoma effect.

Original languageEnglish (US)
Pages (from-to)1-17
Number of pages17
JournalBone Marrow Transplantation
Volume36
Issue number1
DOIs
StatePublished - Jul 1 2005

Keywords

  • Donor leukocyte infusion (DLI)
  • Graft-versus-lymphoma effect (GVL)
  • Hodgkin's disease (HD)
  • Non-Hodgkin's lymphoma (NHL)
  • Non-myeloablative stem cell transplantation (NST)

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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