The great MYC escape in tumorigenesis

Chi V. Dang, Kathryn A O'Donnell-Mendell, Tarja Juopperi

Research output: Contribution to journalShort survey

72 Scopus citations

Abstract

Increased wild-type MYC expression occurs frequently in human cancers, except in Burkitt's lymphoma, where the translocated MYC allele is frequently mutated at several hotspots, including a major one at threonine-58. Acute MYC expression increases p53 or ARF levels and induces apoptosis, and previous transgenic animal studies revealed frequent inactivating mutations of p53 or p19ARF in transgenic Myc-induced lymphomas. Lowe and coworkers (Hemann et al., 2005) demonstrate that wild-type MYC can also trigger apoptosis by inducing Bim, which neutralizes Bcl-2. In contrast, the MYC point mutants failed to induce Bim, promoting murine lymphomas that escaped both wild-type p53 and p19ARF, and in doing so, evaded apoptosis.

Original languageEnglish (US)
Pages (from-to)177-178
Number of pages2
JournalCancer Cell
Volume8
Issue number3
DOIs
StatePublished - Sep 1 2005

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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