The great MYC escape in tumorigenesis

Chi V. Dang, Kathryn A O'Donnell-Mendell, Tarja Juopperi

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Increased wild-type MYC expression occurs frequently in human cancers, except in Burkitt's lymphoma, where the translocated MYC allele is frequently mutated at several hotspots, including a major one at threonine-58. Acute MYC expression increases p53 or ARF levels and induces apoptosis, and previous transgenic animal studies revealed frequent inactivating mutations of p53 or p19ARF in transgenic Myc-induced lymphomas. Lowe and coworkers (Hemann et al., 2005) demonstrate that wild-type MYC can also trigger apoptosis by inducing Bim, which neutralizes Bcl-2. In contrast, the MYC point mutants failed to induce Bim, promoting murine lymphomas that escaped both wild-type p53 and p19ARF, and in doing so, evaded apoptosis.

Original languageEnglish (US)
Pages (from-to)177-178
Number of pages2
JournalCancer Cell
Volume8
Issue number3
DOIs
StatePublished - Sep 2005

Fingerprint

Carcinogenesis
Apoptosis
Lymphoma
Genetically Modified Animals
Burkitt Lymphoma
Threonine
Alleles
Mutation
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Oncology

Cite this

The great MYC escape in tumorigenesis. / Dang, Chi V.; O'Donnell-Mendell, Kathryn A; Juopperi, Tarja.

In: Cancer Cell, Vol. 8, No. 3, 09.2005, p. 177-178.

Research output: Contribution to journalArticle

Dang, Chi V. ; O'Donnell-Mendell, Kathryn A ; Juopperi, Tarja. / The great MYC escape in tumorigenesis. In: Cancer Cell. 2005 ; Vol. 8, No. 3. pp. 177-178.
@article{3361ea21a09a4ab09cffc9c568791f72,
title = "The great MYC escape in tumorigenesis",
abstract = "Increased wild-type MYC expression occurs frequently in human cancers, except in Burkitt's lymphoma, where the translocated MYC allele is frequently mutated at several hotspots, including a major one at threonine-58. Acute MYC expression increases p53 or ARF levels and induces apoptosis, and previous transgenic animal studies revealed frequent inactivating mutations of p53 or p19ARF in transgenic Myc-induced lymphomas. Lowe and coworkers (Hemann et al., 2005) demonstrate that wild-type MYC can also trigger apoptosis by inducing Bim, which neutralizes Bcl-2. In contrast, the MYC point mutants failed to induce Bim, promoting murine lymphomas that escaped both wild-type p53 and p19ARF, and in doing so, evaded apoptosis.",
author = "Dang, {Chi V.} and O'Donnell-Mendell, {Kathryn A} and Tarja Juopperi",
year = "2005",
month = "9",
doi = "10.1016/j.ccr.2005.08.005",
language = "English (US)",
volume = "8",
pages = "177--178",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "3",

}

TY - JOUR

T1 - The great MYC escape in tumorigenesis

AU - Dang, Chi V.

AU - O'Donnell-Mendell, Kathryn A

AU - Juopperi, Tarja

PY - 2005/9

Y1 - 2005/9

N2 - Increased wild-type MYC expression occurs frequently in human cancers, except in Burkitt's lymphoma, where the translocated MYC allele is frequently mutated at several hotspots, including a major one at threonine-58. Acute MYC expression increases p53 or ARF levels and induces apoptosis, and previous transgenic animal studies revealed frequent inactivating mutations of p53 or p19ARF in transgenic Myc-induced lymphomas. Lowe and coworkers (Hemann et al., 2005) demonstrate that wild-type MYC can also trigger apoptosis by inducing Bim, which neutralizes Bcl-2. In contrast, the MYC point mutants failed to induce Bim, promoting murine lymphomas that escaped both wild-type p53 and p19ARF, and in doing so, evaded apoptosis.

AB - Increased wild-type MYC expression occurs frequently in human cancers, except in Burkitt's lymphoma, where the translocated MYC allele is frequently mutated at several hotspots, including a major one at threonine-58. Acute MYC expression increases p53 or ARF levels and induces apoptosis, and previous transgenic animal studies revealed frequent inactivating mutations of p53 or p19ARF in transgenic Myc-induced lymphomas. Lowe and coworkers (Hemann et al., 2005) demonstrate that wild-type MYC can also trigger apoptosis by inducing Bim, which neutralizes Bcl-2. In contrast, the MYC point mutants failed to induce Bim, promoting murine lymphomas that escaped both wild-type p53 and p19ARF, and in doing so, evaded apoptosis.

UR - http://www.scopus.com/inward/record.url?scp=24944527469&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=24944527469&partnerID=8YFLogxK

U2 - 10.1016/j.ccr.2005.08.005

DO - 10.1016/j.ccr.2005.08.005

M3 - Article

C2 - 16169462

AN - SCOPUS:24944527469

VL - 8

SP - 177

EP - 178

JO - Cancer Cell

JF - Cancer Cell

SN - 1535-6108

IS - 3

ER -