The growth of hemopoietic stem cells is inhibited by natural killers only in the nonsyngeneic microenvironment

A. V. Pirozhkov, I. M. Dozmorov, R. V. Petrov

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The growth of hemopoietic cells of some inbred animal lines is repressed in hybrids of the first generation (FJ—the phenomenon of hybrid resistance. We have investigated the mechanism of hybrid resistance by studying the growth of hemopoietic cells of C57BL/6 mice in syngeneic and semisyngeneic heterotopic hemopoietic foci formed under the kidney capsule in (CBA*C57BL/6)F1 recipient mice. We found that hybrid resistance depended upon the joint involvement of NK cells and semisyngeneic hemopoietic stroma. It is concluded that NK cells recognize antigenic markers appearing on target cells located in a nonsyngeneic microenvironment.

Original languageEnglish (US)
Pages (from-to)345-349
Number of pages5
JournalTransplantation
Volume58
Issue number3
StatePublished - Aug 1994

ASJC Scopus subject areas

  • Transplantation

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