The growth of hemopoietic cells of some inbred animal lines is repressed in hybrids of the first generation (FJ—the phenomenon of hybrid resistance. We have investigated the mechanism of hybrid resistance by studying the growth of hemopoietic cells of C57BL/6 mice in syngeneic and semisyngeneic heterotopic hemopoietic foci formed under the kidney capsule in (CBA*C57BL/6)F1 recipient mice. We found that hybrid resistance depended upon the joint involvement of NK cells and semisyngeneic hemopoietic stroma. It is concluded that NK cells recognize antigenic markers appearing on target cells located in a nonsyngeneic microenvironment.
|Original language||English (US)|
|Number of pages||5|
|State||Published - Aug 1994|
ASJC Scopus subject areas