The HIF family member EPAS1/HIF-2α is required for normal hematopoiesis in mice

Marzia Scortegagna, Margaret A. Morris, Yavuz Oktay, Michael Bennett, Joseph A. Garcia

Research output: Contribution to journalArticlepeer-review

141 Scopus citations

Abstract

Hypoxic stress plays a role in pathophysiologic states such as myocardial infarction and cerebral vascular events as well as in normal physiologic conditions including development and hematopoiesis. Members of the hypoxia inducible factor (HIF) family function as transcriptional regulators of genes involved in the hypoxic response. After generating adult mice that globally lack endothelial PAS domain protein 1 (EPAS1, also known as HIF-2α/HRF/HLF/MOP3), the second member of the HIF family, characterization of the hematopoietic cell population indicated that the loss of EPAS1/HIF-2α resulted in pancytopenia. Using bone marrow reconstitution experiments of lethally irradiated hosts, we have defined the extent and site of hematopoietic impairment in the EPAS1/HIF-2α null mice. These data suggest a critical role for EPAS1/HIF-2α in maintaining a functional microenvironment in the bone marrow for effective hematopoiesis.

Original languageEnglish (US)
Pages (from-to)1634-1640
Number of pages7
JournalBlood
Volume102
Issue number5
DOIs
StatePublished - Sep 1 2003

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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