The Hippo Signaling Pathway in Development and Disease

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction has been implicated in an increasing number of human diseases, including cancer. Here, we provide an updated review of the Hippo pathway; discuss its roles in development, homeostasis, regeneration, and diseases; and highlight outstanding questions for future investigation and opportunities for Hippo-targeted therapies.

Original languageEnglish (US)
JournalDevelopmental Cell
DOIs
StatePublished - Jan 1 2019

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Keywords

  • actomyosin
  • adherens junction
  • cancer
  • cell polarity
  • cytoskeleton
  • growth control
  • hippo signaling
  • mechanotransduction
  • merlin
  • neurofibromatosis
  • NF2
  • oncogene
  • regeneration
  • scalloped
  • spectrin
  • TAZ
  • TEAD
  • tissue homeostasis
  • tumor suppressor
  • YAP
  • yorkie

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

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