The Hippo Signaling Pathway in Development and Disease

Yonggang Zheng, Duojia Pan Ph.D.

Research output: Contribution to journalReview article

Abstract

The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction has been implicated in an increasing number of human diseases, including cancer. Here, we provide an updated review of the Hippo pathway; discuss its roles in development, homeostasis, regeneration, and diseases; and highlight outstanding questions for future investigation and opportunities for Hippo-targeted therapies.

Original languageEnglish (US)
JournalDevelopmental Cell
DOIs
StatePublished - Jan 1 2019

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Physiological Phenomena
Regeneration
Homeostasis
Neoplasms
Therapeutics

Keywords

  • actomyosin
  • adherens junction
  • cancer
  • cell polarity
  • cytoskeleton
  • growth control
  • hippo signaling
  • mechanotransduction
  • merlin
  • neurofibromatosis
  • NF2
  • oncogene
  • regeneration
  • scalloped
  • spectrin
  • TAZ
  • TEAD
  • tissue homeostasis
  • tumor suppressor
  • YAP
  • yorkie

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

Cite this

The Hippo Signaling Pathway in Development and Disease. / Zheng, Yonggang; Pan Ph.D., Duojia.

In: Developmental Cell, 01.01.2019.

Research output: Contribution to journalReview article

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