Abstract
Although a developmental role for Hippo signaling in organ size control is well appreciated, how this pathway functions in tissue regeneration is largely unknown. Here we address this issue using a dextran sodium sulfate (DSS)-induced colonic regeneration model. We find that regenerating crypts express elevated Yes-associated protein (YAP) levels. Inactivation of YAP causes no obvious intestinal defects under normal homeostasis, but severely impairs DSS-induced intestinal regeneration. Conversely, hyperactivation of YAP results in widespread early-onset polyp formation following DSS treatment. Thus, the YAP oncoprotein must be exquisitely controlled in tissue regeneration to allow compensatory proliferation and prevent the intrinsic oncogenic potential of a tissue regeneration program.
Original language | English (US) |
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Pages (from-to) | 2383-2388 |
Number of pages | 6 |
Journal | Genes and Development |
Volume | 24 |
Issue number | 21 |
DOIs | |
State | Published - Nov 1 2010 |
Keywords
- Cancer
- Growth control
- Hippo signaling
- Mouse
- Regeneration
ASJC Scopus subject areas
- Genetics
- Developmental Biology