@article{81379dea2d2d469eae6c37866fb13b99,
title = "The HL-60 transforming sequence: A ras oncogene coexisting with altered myc genes in hematopoietic tumors",
abstract = "The oncogene of the HL-60 human promyelocytic leukemia cell line has been passed serially through NIH/3T3 mouse fibroblasts. Oncogene-specific probes prepared from the resulting tertiary transfectants by molecular cloning have been used to show that loss of the transfected oncogene from NIH/3T3 cells correlates with reversion to nontransformed morphology. Analysis of cells transfected by the oncogenes of other tumors and tumor cell lines indicates that the transforming gene of the HL-60 leukemia cell line is closely related to oncogenes of a Burkitt's lymphoma, an acute myelogenous leukemia, an adenocarcinoma of the colon, a neuroblastoma, and two sarcomas. This oncogene is distantly related to the viral oncogenes of Kirsten and Harvey sarcoma viruses. It has been termed N-ras. The active N-ras oncogene coexists with altered versions of the myc oncogene in the HL-60 and AW Ramos human tumors. This suggests a multistep mechanism involving both ras and myc genes in the creation of these tumors.",
author = "Murray, {Mark J.} and Cunningham, {James M.} and Parada, {Luis F.} and Francois Dautry and Paul Lebowitz and Weinberg, {Robert A.}",
note = "Funding Information: We acknowledge the excellent technlcal assistance of Deborah Cowing, Lalitha Vardyanathan, and Ann Dannenberg Rosen. We thank Susan Posner for her great help in preparing the manuscript. Drs. Michael Bishop, Edward Scolnlck, Douglas Lowy. Henry Kronenberg, and Robert Schrmke generously provided clones used rn various aspects of this study. We acknowledge the generosity and cooperation of Drs. Mrchael Wigler, Alan Hall, and Chrtstopher Marshall for providing DNAs and molecular clones of transfected oncogenes. M. M. J. was a fellow of the Aid for Cancer Research of Newton, Massachusetts. J. M. C. was supported by an American Cancer Society postdoctoral fellowship. F. D. was supported by an EMBO fellow-shop. This research was supported by NCI grants CA26717 and CA17537 as well as a grant from the Whitehead Charitable Foundatton. The costs of publicatron of this article were defrayed in pan by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Sectron 1734 solely to indicate this fact,",
year = "1983",
month = jul,
doi = "10.1016/0092-8674(83)90017-X",
language = "English (US)",
volume = "33",
pages = "749--757",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "3",
}