The immunobiology of Acanthamoeba keratitis

Daniel W. Clarke; Jerry Y. Niederkorn

doi:10.1016/j.micinf.2005.12.009

The immunobiology of Acanthamoeba keratitis

Daniel W. Clarke, Jerry Y. Niederkorn

Research output: Contribution to journal › Short survey › peer-review

47 Scopus citations

Abstract

Acanthamoeba spp. are free-living amoebae that cause Acanthamoeba keratitis, a blinding corneal infection. The innate immune apparatus is crucial for the resolution of the disease. With the exception of mucosal antibody, elements of the adaptive immune system fail to prevent infection or contribute to its resolution in experimental animals.

Original language	English (US)
Pages (from-to)	1400-1405
Number of pages	6
Journal	Microbes and Infection
Volume	8
Issue number	5
DOIs	https://doi.org/10.1016/j.micinf.2005.12.009
State	Published - Apr 2006

Keywords

Amoeba
Cornea
Immunology
Keratitis

ASJC Scopus subject areas

Microbiology
Immunology
Infectious Diseases

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10.1016/j.micinf.2005.12.009

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title = "The immunobiology of Acanthamoeba keratitis",

abstract = "Acanthamoeba spp. are free-living amoebae that cause Acanthamoeba keratitis, a blinding corneal infection. The innate immune apparatus is crucial for the resolution of the disease. With the exception of mucosal antibody, elements of the adaptive immune system fail to prevent infection or contribute to its resolution in experimental animals.",

keywords = "Amoeba, Cornea, Immunology, Keratitis",

author = "Clarke, {Daniel W.} and Niederkorn, {Jerry Y.}",

note = "Funding Information: This work was supported by NIH grant EY09756, NIH grant R24 EY016664, and an unrestricted grant from Research to Prevent Blindness, Inc., New York, NY.",

year = "2006",

month = apr,

doi = "10.1016/j.micinf.2005.12.009",

language = "English (US)",

volume = "8",

pages = "1400--1405",

journal = "Microbes and Infection",

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TY - JOUR

T1 - The immunobiology of Acanthamoeba keratitis

AU - Clarke, Daniel W.

AU - Niederkorn, Jerry Y.

N1 - Funding Information: This work was supported by NIH grant EY09756, NIH grant R24 EY016664, and an unrestricted grant from Research to Prevent Blindness, Inc., New York, NY.

PY - 2006/4

Y1 - 2006/4

N2 - Acanthamoeba spp. are free-living amoebae that cause Acanthamoeba keratitis, a blinding corneal infection. The innate immune apparatus is crucial for the resolution of the disease. With the exception of mucosal antibody, elements of the adaptive immune system fail to prevent infection or contribute to its resolution in experimental animals.

AB - Acanthamoeba spp. are free-living amoebae that cause Acanthamoeba keratitis, a blinding corneal infection. The innate immune apparatus is crucial for the resolution of the disease. With the exception of mucosal antibody, elements of the adaptive immune system fail to prevent infection or contribute to its resolution in experimental animals.

KW - Amoeba

KW - Cornea

KW - Immunology

KW - Keratitis

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U2 - 10.1016/j.micinf.2005.12.009

DO - 10.1016/j.micinf.2005.12.009

M3 - Short survey

C2 - 16697233

AN - SCOPUS:33744828507

SN - 1286-4579

VL - 8

SP - 1400

EP - 1405

JO - Microbes and Infection

JF - Microbes and Infection

IS - 5

ER -

The immunobiology of Acanthamoeba keratitis

Abstract

Keywords

ASJC Scopus subject areas

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