The Impact of Delayed Surgery on Radiotherapy Dose and Local Control of Rhabdomyosarcoma

Erlinda Etcubanas, Bhaskar N. Rao, Larry E. Kun, Marc E. Horowitz, David M. Parham, H. Omar Hustu, Alexander A. Green

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

To determine if delayed surgery permits the modification of radiotherapy dose while maintaining local control in children with localized, unresectable rhabdomyosarcoma, a prospective study was launched in 1981 to test this objective. Treatment consisted of 16 weeks of preoperative chemotherapy, with or without delayed surgery, and radiotherapy using 35 to 40 Gy (3500 to 4000 rad) for microscopic and 50 to 55 Gy (5000 to 5500 rad) for gross residual tumor, plus 14 months of chemotherapy. Among 22 patients treated, surgery was feasible in 11 of 14 patients with residual tumor after chemotherapy and was performed in eight (avoiding radical surgery in three), leaving microscopic (seven patients) or gross residual (one patient) tumor. Progressive disease or amputation precluded radiotherapy in two patients. After radiotherapy local control was sustained in 12 of 14 patients with microscopic lesions vs none of six patients with gross tumor. Delayed surgery may permit the use of lower-dose radiotherapy and should be considered in the treatment plan for this subset of patients.

Original languageEnglish (US)
Pages (from-to)1451-1454
Number of pages4
JournalArchives of Surgery
Volume122
Issue number12
DOIs
StatePublished - Jan 1 1987

Fingerprint

Rhabdomyosarcoma
Radiotherapy
Residual Neoplasm
Drug Therapy
Amputation
Neoplasms
Prospective Studies
Therapeutics

ASJC Scopus subject areas

  • Surgery

Cite this

Etcubanas, E., Rao, B. N., Kun, L. E., Horowitz, M. E., Parham, D. M., Hustu, H. O., & Green, A. A. (1987). The Impact of Delayed Surgery on Radiotherapy Dose and Local Control of Rhabdomyosarcoma. Archives of Surgery, 122(12), 1451-1454. https://doi.org/10.1001/archsurg.1987.01400240099018

The Impact of Delayed Surgery on Radiotherapy Dose and Local Control of Rhabdomyosarcoma. / Etcubanas, Erlinda; Rao, Bhaskar N.; Kun, Larry E.; Horowitz, Marc E.; Parham, David M.; Hustu, H. Omar; Green, Alexander A.

In: Archives of Surgery, Vol. 122, No. 12, 01.01.1987, p. 1451-1454.

Research output: Contribution to journalArticle

Etcubanas, E, Rao, BN, Kun, LE, Horowitz, ME, Parham, DM, Hustu, HO & Green, AA 1987, 'The Impact of Delayed Surgery on Radiotherapy Dose and Local Control of Rhabdomyosarcoma', Archives of Surgery, vol. 122, no. 12, pp. 1451-1454. https://doi.org/10.1001/archsurg.1987.01400240099018
Etcubanas, Erlinda ; Rao, Bhaskar N. ; Kun, Larry E. ; Horowitz, Marc E. ; Parham, David M. ; Hustu, H. Omar ; Green, Alexander A. / The Impact of Delayed Surgery on Radiotherapy Dose and Local Control of Rhabdomyosarcoma. In: Archives of Surgery. 1987 ; Vol. 122, No. 12. pp. 1451-1454.
@article{e09e099872094efb9d13632724be6e66,
title = "The Impact of Delayed Surgery on Radiotherapy Dose and Local Control of Rhabdomyosarcoma",
abstract = "To determine if delayed surgery permits the modification of radiotherapy dose while maintaining local control in children with localized, unresectable rhabdomyosarcoma, a prospective study was launched in 1981 to test this objective. Treatment consisted of 16 weeks of preoperative chemotherapy, with or without delayed surgery, and radiotherapy using 35 to 40 Gy (3500 to 4000 rad) for microscopic and 50 to 55 Gy (5000 to 5500 rad) for gross residual tumor, plus 14 months of chemotherapy. Among 22 patients treated, surgery was feasible in 11 of 14 patients with residual tumor after chemotherapy and was performed in eight (avoiding radical surgery in three), leaving microscopic (seven patients) or gross residual (one patient) tumor. Progressive disease or amputation precluded radiotherapy in two patients. After radiotherapy local control was sustained in 12 of 14 patients with microscopic lesions vs none of six patients with gross tumor. Delayed surgery may permit the use of lower-dose radiotherapy and should be considered in the treatment plan for this subset of patients.",
author = "Erlinda Etcubanas and Rao, {Bhaskar N.} and Kun, {Larry E.} and Horowitz, {Marc E.} and Parham, {David M.} and Hustu, {H. Omar} and Green, {Alexander A.}",
year = "1987",
month = "1",
day = "1",
doi = "10.1001/archsurg.1987.01400240099018",
language = "English (US)",
volume = "122",
pages = "1451--1454",
journal = "JAMA Surgery",
issn = "2168-6254",
publisher = "American Medical Association",
number = "12",

}

TY - JOUR

T1 - The Impact of Delayed Surgery on Radiotherapy Dose and Local Control of Rhabdomyosarcoma

AU - Etcubanas, Erlinda

AU - Rao, Bhaskar N.

AU - Kun, Larry E.

AU - Horowitz, Marc E.

AU - Parham, David M.

AU - Hustu, H. Omar

AU - Green, Alexander A.

PY - 1987/1/1

Y1 - 1987/1/1

N2 - To determine if delayed surgery permits the modification of radiotherapy dose while maintaining local control in children with localized, unresectable rhabdomyosarcoma, a prospective study was launched in 1981 to test this objective. Treatment consisted of 16 weeks of preoperative chemotherapy, with or without delayed surgery, and radiotherapy using 35 to 40 Gy (3500 to 4000 rad) for microscopic and 50 to 55 Gy (5000 to 5500 rad) for gross residual tumor, plus 14 months of chemotherapy. Among 22 patients treated, surgery was feasible in 11 of 14 patients with residual tumor after chemotherapy and was performed in eight (avoiding radical surgery in three), leaving microscopic (seven patients) or gross residual (one patient) tumor. Progressive disease or amputation precluded radiotherapy in two patients. After radiotherapy local control was sustained in 12 of 14 patients with microscopic lesions vs none of six patients with gross tumor. Delayed surgery may permit the use of lower-dose radiotherapy and should be considered in the treatment plan for this subset of patients.

AB - To determine if delayed surgery permits the modification of radiotherapy dose while maintaining local control in children with localized, unresectable rhabdomyosarcoma, a prospective study was launched in 1981 to test this objective. Treatment consisted of 16 weeks of preoperative chemotherapy, with or without delayed surgery, and radiotherapy using 35 to 40 Gy (3500 to 4000 rad) for microscopic and 50 to 55 Gy (5000 to 5500 rad) for gross residual tumor, plus 14 months of chemotherapy. Among 22 patients treated, surgery was feasible in 11 of 14 patients with residual tumor after chemotherapy and was performed in eight (avoiding radical surgery in three), leaving microscopic (seven patients) or gross residual (one patient) tumor. Progressive disease or amputation precluded radiotherapy in two patients. After radiotherapy local control was sustained in 12 of 14 patients with microscopic lesions vs none of six patients with gross tumor. Delayed surgery may permit the use of lower-dose radiotherapy and should be considered in the treatment plan for this subset of patients.

UR - http://www.scopus.com/inward/record.url?scp=0023576688&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023576688&partnerID=8YFLogxK

U2 - 10.1001/archsurg.1987.01400240099018

DO - 10.1001/archsurg.1987.01400240099018

M3 - Article

C2 - 3689122

AN - SCOPUS:0023576688

VL - 122

SP - 1451

EP - 1454

JO - JAMA Surgery

JF - JAMA Surgery

SN - 2168-6254

IS - 12

ER -