The impact of location and number of cores on the diagnostic accuracy of renal mass biopsy: An ex vivo study

David J. Hobbs, Ming Zhou, Steven C. Campbell, Hakan Aydin, Christopher J. Weight, Brian R. Lane

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objective: To evaluate whether renal mass biopsy (RMB) biopsy location or number affected diagnostic accuracy in a prospective ex vivo study. Methods: Three cores (1 central and 2 peripheral) were obtained for histologic processing from each of 48 renal masses after nephrectomy. Individual biopsy cores were evaluated independently for tumor subtype and grade by a single, blinded GU pathologist. Results: Although individual biopsy cores were informative and confirmed accurate in only 59 % of samples, accuracy increased to 85 % with three-core biopsy (p < 0.01). Cancer identification with a single peripheral core increased to 77 % by adding a central core (p = 0.005), to 80 % with a second peripheral core (p = 0.008), and to 85 % with three cores (p = 0.001). Similarly, diagnostic yield for histologic subtyping increased from 44 % for 1-core biopsy to 59-63 % with 2-core biopsy (p = 0.03) and to 67 % with 3-core biopsy (p = 0.02). The correct subtype was confirmed at nephrectomy for 63 % of clear cell RCC, 60 % of papillary RCC, 100 % of chromophobe RCC and 75 % of oncocytomas. When recorded, nuclear grade corresponded to final grade assignment in 56 % and was within 1 grade in an additional 37 %. Conclusions: RMB has not been used routinely in the evaluation of renal cortical neoplasms because of reportedly high rates of indeterminate or inaccurate diagnoses. In this prospective, ex vivo study, single-core RMB results in a low diagnostic yield. Obtaining multiple cores significantly improved diagnostic yield, with similar results with two-core and three-core RMB. We therefore recommend that RMB for suspicion of cancer include at least two peripheral cores.

Original languageEnglish (US)
Pages (from-to)1159-1164
Number of pages6
JournalWorld Journal of Urology
Volume31
Issue number5
DOIs
StatePublished - Oct 1 2013

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Kidney
Biopsy
Nephrectomy
Oxyphilic Adenoma
Neoplasms
Kidney Neoplasms

Keywords

  • Biopsy
  • Carcinoma
  • Kidney neoplasms
  • Nephrectomy
  • Renal cell

ASJC Scopus subject areas

  • Urology

Cite this

The impact of location and number of cores on the diagnostic accuracy of renal mass biopsy : An ex vivo study. / Hobbs, David J.; Zhou, Ming; Campbell, Steven C.; Aydin, Hakan; Weight, Christopher J.; Lane, Brian R.

In: World Journal of Urology, Vol. 31, No. 5, 01.10.2013, p. 1159-1164.

Research output: Contribution to journalArticle

Hobbs, David J. ; Zhou, Ming ; Campbell, Steven C. ; Aydin, Hakan ; Weight, Christopher J. ; Lane, Brian R. / The impact of location and number of cores on the diagnostic accuracy of renal mass biopsy : An ex vivo study. In: World Journal of Urology. 2013 ; Vol. 31, No. 5. pp. 1159-1164.
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abstract = "Objective: To evaluate whether renal mass biopsy (RMB) biopsy location or number affected diagnostic accuracy in a prospective ex vivo study. Methods: Three cores (1 central and 2 peripheral) were obtained for histologic processing from each of 48 renal masses after nephrectomy. Individual biopsy cores were evaluated independently for tumor subtype and grade by a single, blinded GU pathologist. Results: Although individual biopsy cores were informative and confirmed accurate in only 59 {\%} of samples, accuracy increased to 85 {\%} with three-core biopsy (p < 0.01). Cancer identification with a single peripheral core increased to 77 {\%} by adding a central core (p = 0.005), to 80 {\%} with a second peripheral core (p = 0.008), and to 85 {\%} with three cores (p = 0.001). Similarly, diagnostic yield for histologic subtyping increased from 44 {\%} for 1-core biopsy to 59-63 {\%} with 2-core biopsy (p = 0.03) and to 67 {\%} with 3-core biopsy (p = 0.02). The correct subtype was confirmed at nephrectomy for 63 {\%} of clear cell RCC, 60 {\%} of papillary RCC, 100 {\%} of chromophobe RCC and 75 {\%} of oncocytomas. When recorded, nuclear grade corresponded to final grade assignment in 56 {\%} and was within 1 grade in an additional 37 {\%}. Conclusions: RMB has not been used routinely in the evaluation of renal cortical neoplasms because of reportedly high rates of indeterminate or inaccurate diagnoses. In this prospective, ex vivo study, single-core RMB results in a low diagnostic yield. Obtaining multiple cores significantly improved diagnostic yield, with similar results with two-core and three-core RMB. We therefore recommend that RMB for suspicion of cancer include at least two peripheral cores.",
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AB - Objective: To evaluate whether renal mass biopsy (RMB) biopsy location or number affected diagnostic accuracy in a prospective ex vivo study. Methods: Three cores (1 central and 2 peripheral) were obtained for histologic processing from each of 48 renal masses after nephrectomy. Individual biopsy cores were evaluated independently for tumor subtype and grade by a single, blinded GU pathologist. Results: Although individual biopsy cores were informative and confirmed accurate in only 59 % of samples, accuracy increased to 85 % with three-core biopsy (p < 0.01). Cancer identification with a single peripheral core increased to 77 % by adding a central core (p = 0.005), to 80 % with a second peripheral core (p = 0.008), and to 85 % with three cores (p = 0.001). Similarly, diagnostic yield for histologic subtyping increased from 44 % for 1-core biopsy to 59-63 % with 2-core biopsy (p = 0.03) and to 67 % with 3-core biopsy (p = 0.02). The correct subtype was confirmed at nephrectomy for 63 % of clear cell RCC, 60 % of papillary RCC, 100 % of chromophobe RCC and 75 % of oncocytomas. When recorded, nuclear grade corresponded to final grade assignment in 56 % and was within 1 grade in an additional 37 %. Conclusions: RMB has not been used routinely in the evaluation of renal cortical neoplasms because of reportedly high rates of indeterminate or inaccurate diagnoses. In this prospective, ex vivo study, single-core RMB results in a low diagnostic yield. Obtaining multiple cores significantly improved diagnostic yield, with similar results with two-core and three-core RMB. We therefore recommend that RMB for suspicion of cancer include at least two peripheral cores.

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