TY - JOUR
T1 - The impact of negative-pressure wound therapy with instillation compared with standard negative-pressure wound therapy
T2 - A retrospective, historical, cohort, controlled study
AU - Kim, Paul J.
AU - Attinger, Christopher E.
AU - Steinberg, John S.
AU - Evans, Karen K.
AU - Powers, Kelly A.
AU - Hung, Rex W.
AU - Smith, Jesse R.
AU - Rocha, Zinnia M.
AU - Lavery, Larry
PY - 2014/3
Y1 - 2014/3
N2 - Background: Negative-pressure wound therapy with instillation is a novel wound therapy that combines negative pressure with instillation of a topical solution. Methods: This retrospective, historical, cohort-control study examined the impact of negative-pressure wound therapy with and without instillation. Results: One hundred forty-two patients (negative-pressure wound therapy, n = 74; therapy with instillation, 6-minute dwell time, n = 34; and therapy with instillation, 20-minute dwell time, n = 34) were included in the analysis. Number of operative visits was significantly lower for the 6-and 20-minute dwell time groups (2.4 ± 0.9 and 2.6 ± 0.9, respectively) compared with the no-instillation group (3.0 ± 0.9) (p ≤ 0.05). Hospital stay was significantly shorter for the 20-minute dwell time group (11.4 ± 5.1 days) compared with the no-instillation group (14.92 ± 9.23 days) (p ≤ 0.05). Time to final surgical procedure was significantly shorter for the 6-and 20-minute dwell time groups (7.8 ± 5.2 and 7.5 ± 3.1 days, respectively) compared with the no-instillation group (9.23 ± 5.2 days) (p ≤ 0.05). Percentage of wounds closed before discharge and culture improvement for Gram-positive bacteria was significantly higher for the 6-minute dwell time group (94 and 90 percent, respectively) compared with the no-instillation group (62 and 63 percent, respectively) (p ≤ 0.05). Conclusion: The authors' results suggest that negative-pressure wound therapy with instillation (6-or 20-minute dwell time) is more beneficial than standard negative-pressure wound therapy for the adjunctive treatment of acutely and chronically infected wounds that require hospital admission.
AB - Background: Negative-pressure wound therapy with instillation is a novel wound therapy that combines negative pressure with instillation of a topical solution. Methods: This retrospective, historical, cohort-control study examined the impact of negative-pressure wound therapy with and without instillation. Results: One hundred forty-two patients (negative-pressure wound therapy, n = 74; therapy with instillation, 6-minute dwell time, n = 34; and therapy with instillation, 20-minute dwell time, n = 34) were included in the analysis. Number of operative visits was significantly lower for the 6-and 20-minute dwell time groups (2.4 ± 0.9 and 2.6 ± 0.9, respectively) compared with the no-instillation group (3.0 ± 0.9) (p ≤ 0.05). Hospital stay was significantly shorter for the 20-minute dwell time group (11.4 ± 5.1 days) compared with the no-instillation group (14.92 ± 9.23 days) (p ≤ 0.05). Time to final surgical procedure was significantly shorter for the 6-and 20-minute dwell time groups (7.8 ± 5.2 and 7.5 ± 3.1 days, respectively) compared with the no-instillation group (9.23 ± 5.2 days) (p ≤ 0.05). Percentage of wounds closed before discharge and culture improvement for Gram-positive bacteria was significantly higher for the 6-minute dwell time group (94 and 90 percent, respectively) compared with the no-instillation group (62 and 63 percent, respectively) (p ≤ 0.05). Conclusion: The authors' results suggest that negative-pressure wound therapy with instillation (6-or 20-minute dwell time) is more beneficial than standard negative-pressure wound therapy for the adjunctive treatment of acutely and chronically infected wounds that require hospital admission.
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U2 - 10.1097/01.prs.0000438060.46290.7a
DO - 10.1097/01.prs.0000438060.46290.7a
M3 - Article
C2 - 24572860
AN - SCOPUS:84897785851
SN - 0032-1052
VL - 133
SP - 709
EP - 716
JO - Plastic and reconstructive surgery
JF - Plastic and reconstructive surgery
IS - 3
ER -