Die bedeutung der negativsymptomatik für kognitive defizite bei patienten mit erstmanifestation einer schizophrenie

Translated title of the contribution: The impact of negative symptoms on cognitive performance in treatment-naive patients with first-episode schizophrenia

Daniel Schüpbach, M. S. Harris, M. S. Keshavan, J. A. Sweeney

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Patients with a first episode of schizophrenia may suffer from psychotic and disorganised symptoms, such as delusions, hallucination, bizarre behaviour and formal thought disorder, and from negative symptoms including flattening of affect, alogia, apathy/avolition, anhedonia and deficits in attention. There is solid evidence that neuropsychological abnormalities are also present at this stage of the illness, comprising deficits in domains of attention, executive function, verbal and non-verbal memory, spatial abilities, psychomotor functions, etc. We have recently shown that early, treatment-induced improvement of negative symptoms is significantly associated with cognitive performance during a follow-up period of two years. In this study the impact of early, treatment-induced change of negative symptoms on cognitive performance during a follow-up of 2 years was examined in a larger sample of neuroleptic-naïve patients with first-episode schizophrenia. Forty-three patients with a diagnosis of schizophrenia or schizoaffective disorder according to DSM-IV underwent a comprehensive clinical and neuropsychological test battery at the time of study inclusion and after approximately 5 weeks, 6, 12 and 24 months of follow-up. A healthy comparison group with similar age, gender distribution and parental socio-economic status was also included. Patients showed marked cognitive deficits at baseline and throughout the follow-up. Early, treatment-induced improvement of negative symptoms predicted better cognitive performance at follow-up. Early, treatment-induced improvement of cognitive performance was significantly associated with less negative and psychotic symptoms. The results of this study suggest a clinical relevant association between early change in negative symptoms and cognitive outcome, and between early improvement of cognitive performance and symptomatic outcome. Negative symptoms and cognitive deficits should be considered as primary treatment targets in the early course of schizophrenia.

Original languageGerman
Pages (from-to)32-38
Number of pages7
JournalSchweizer Archiv fur Neurologie und Psychiatrie
Volume158
Issue number1
StatePublished - Jan 2007

Fingerprint

Neurobehavioral Manifestations
Schizophrenia
Anhedonia
Therapeutics
Apathy
Delusions
Time and Motion Studies
Neuropsychological Tests
Hallucinations
Aphasia
Age Distribution
Executive Function
Diagnostic and Statistical Manual of Mental Disorders
Psychotic Disorders
Antipsychotic Agents
Economics

Keywords

  • Cognitive deficits
  • First-episode schizophrenia
  • Negative symptoms

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Die bedeutung der negativsymptomatik für kognitive defizite bei patienten mit erstmanifestation einer schizophrenie. / Schüpbach, Daniel; Harris, M. S.; Keshavan, M. S.; Sweeney, J. A.

In: Schweizer Archiv fur Neurologie und Psychiatrie, Vol. 158, No. 1, 01.2007, p. 32-38.

Research output: Contribution to journalArticle

Schüpbach, Daniel ; Harris, M. S. ; Keshavan, M. S. ; Sweeney, J. A. / Die bedeutung der negativsymptomatik für kognitive defizite bei patienten mit erstmanifestation einer schizophrenie. In: Schweizer Archiv fur Neurologie und Psychiatrie. 2007 ; Vol. 158, No. 1. pp. 32-38.
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