The Impact of Obesity on Urinary Incontinence Symptoms, Severity, Urodynamic Characteristics and Quality of Life

Holly E. Richter, Kimberly Kenton, Liyuan Huang, Ingrid Nygaard, Stephen Kraus, Emily Whitcomb, Toby C. Chai, Gary Lemack, Larry Sirls, Kimberly J. Dandreo, Anne Stoddard

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Purpose: We compared urinary incontinence severity measures and the impact of stress urinary incontinence in normal, overweight and obese women. Materials and Methods: Baseline characteristics of subjects in the SISTEr (655) and the TOMUS (597) were analyzed. Body mass index was defined as normal (less than 25 kg/m2), overweight (25 to less than 30 kg/m2) and obese (30 kg/m2 or greater). Independent urinary incontinence severity measures included a 3-day diary including incontinence episode frequency, Urogenital Distress Inventory scores and Valsalva leak point pressure from urodynamic testing. Impact was measured using the Incontinence Impact Questionnaire. Multivariable regression models were fit for each severity measure (Urogenital Distress Inventory, incontinence episode frequency, Valsalva leak point pressure and Incontinence Impact Questionnaire) on weight category. Covariates included age, race, diabetes and variables significantly associated with body mass index on bivariate analysis. Results: Mean age (SD) of participants was 51.9 (10.3) in SISTEr and 52.9 (11.0) in TOMUS. In each trial 45% of subjects were obese. In SISTEr multivariable regression analyses showed that higher weight category was independently associated with higher mean Urogenital Distress Inventory score (p = 0.003), incontinence episode frequency (p <0.0001), Valsalva leak point pressure (p = 0.003) and Incontinence Impact Questionnaire score (p = 0.0004). In TOMUS higher weight category was not associated with Urogenital Distress Inventory score (p = 0.24) but was associated with higher incontinence episode frequency (p = 0.0003), Valsalva leak point pressure (p = 0.0006) and Incontinence Impact Questionnaire score (p <0.0001). Conclusions: Obese women undergoing surgery for stress urinary incontinence report more incontinence episodes, more symptom distress and worse quality of life despite better measure of urethral function (higher Valsalva leak point pressure) on urodynamics.

Original languageEnglish (US)
Pages (from-to)622-628
Number of pages7
JournalJournal of Urology
Volume183
Issue number2
DOIs
StatePublished - Feb 2010

Fingerprint

Urodynamics
Urinary Incontinence
Obesity
Quality of Life
Pressure
Equipment and Supplies
Stress Urinary Incontinence
Weights and Measures
Body Mass Index
Regression Analysis
Surveys and Questionnaires

Keywords

  • obesity
  • stress
  • urinary incontinence
  • urodynamics

ASJC Scopus subject areas

  • Urology

Cite this

Richter, H. E., Kenton, K., Huang, L., Nygaard, I., Kraus, S., Whitcomb, E., ... Stoddard, A. (2010). The Impact of Obesity on Urinary Incontinence Symptoms, Severity, Urodynamic Characteristics and Quality of Life. Journal of Urology, 183(2), 622-628. https://doi.org/10.1016/j.juro.2009.09.083

The Impact of Obesity on Urinary Incontinence Symptoms, Severity, Urodynamic Characteristics and Quality of Life. / Richter, Holly E.; Kenton, Kimberly; Huang, Liyuan; Nygaard, Ingrid; Kraus, Stephen; Whitcomb, Emily; Chai, Toby C.; Lemack, Gary; Sirls, Larry; Dandreo, Kimberly J.; Stoddard, Anne.

In: Journal of Urology, Vol. 183, No. 2, 02.2010, p. 622-628.

Research output: Contribution to journalArticle

Richter, HE, Kenton, K, Huang, L, Nygaard, I, Kraus, S, Whitcomb, E, Chai, TC, Lemack, G, Sirls, L, Dandreo, KJ & Stoddard, A 2010, 'The Impact of Obesity on Urinary Incontinence Symptoms, Severity, Urodynamic Characteristics and Quality of Life', Journal of Urology, vol. 183, no. 2, pp. 622-628. https://doi.org/10.1016/j.juro.2009.09.083
Richter, Holly E. ; Kenton, Kimberly ; Huang, Liyuan ; Nygaard, Ingrid ; Kraus, Stephen ; Whitcomb, Emily ; Chai, Toby C. ; Lemack, Gary ; Sirls, Larry ; Dandreo, Kimberly J. ; Stoddard, Anne. / The Impact of Obesity on Urinary Incontinence Symptoms, Severity, Urodynamic Characteristics and Quality of Life. In: Journal of Urology. 2010 ; Vol. 183, No. 2. pp. 622-628.
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AU - Kraus, Stephen

AU - Whitcomb, Emily

AU - Chai, Toby C.

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