The impact of peri-shock pause on survival from out-of-hospital shockable cardiac arrest during the Resuscitation Outcomes Consortium PRIMED trial

Sheldon Cheskes, Robert H. Schmicker, P. Richard Verbeek, David D. Salcido, Siobhan P. Brown, Steven Brooks, James J. Menegazzi, Christian Vaillancourt, Judy Powell, Susanne May, Robert A. Berg, Rebecca Sell, Ahamed Idris, Mike Kampp, Terri Schmidt, Jim Christenson

Research output: Contribution to journalArticle

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Abstract

Background: Previous research has demonstrated significant relationships between peri-shock pause and survival to discharge from out-of-hospital shockable cardiac arrest (OHCA). Objective: To determine the impact of peri-shock pause on survival from OHCA during the ROC PRIMED randomized controlled trial. Methods: We included patients in the ROC PRIMED trial who suffered OHCA between June 2007 and November 2009, presented with a shockable rhythm and had CPR process data for at least one shock. We used multivariable logistic regression to determine the association between peri-shock pause duration and survival to hospital discharge. Results: Among 2006 patients studied, the median (IQR) shock pause duration was: pre-shock pause 15. s (8, 22); post-shock pause 6. s (4, 9); and peri-shock pause 22.0. s (14, 31). After adjusting for Utstein predictors of survival as well as CPR quality measures, the odds of survival to hospital discharge were significantly higher for patients with pre-shock pause <10. s (OR: 1.52, 95% CI: 1.09, 2.11) and peri-shock pause <20. s (OR: 1.82, 95% CI: 1.17, 2.85) when compared to patients with pre-shock pause ≥20. s and peri-shock pause ≥40. s. Post-shock pause was not significantly associated with survival to hospital discharge. Results for neurologically intact survival (Modified Rankin Score. ≤. 3) were similar to our primary outcome. Conclusions: In patients with cardiac arrest presenting in a shockable rhythm during the ROC PRIMED trial, shorter pre- and peri-shock pauses were significantly associated with higher odds of survival. Future cardiopulmonary education and technology should focus on minimizing all peri-shock pauses.

Original languageEnglish (US)
Pages (from-to)336-342
Number of pages7
JournalResuscitation
Volume85
Issue number3
DOIs
StatePublished - Mar 2014

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Out-of-Hospital Cardiac Arrest
Resuscitation
Shock
Survival
Cardiopulmonary Resuscitation

Keywords

  • Cardiopulmonary resuscitation
  • Heart arrest
  • Resuscitation
  • Survival

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Emergency
  • Emergency Medicine
  • Medicine(all)

Cite this

The impact of peri-shock pause on survival from out-of-hospital shockable cardiac arrest during the Resuscitation Outcomes Consortium PRIMED trial. / Cheskes, Sheldon; Schmicker, Robert H.; Verbeek, P. Richard; Salcido, David D.; Brown, Siobhan P.; Brooks, Steven; Menegazzi, James J.; Vaillancourt, Christian; Powell, Judy; May, Susanne; Berg, Robert A.; Sell, Rebecca; Idris, Ahamed; Kampp, Mike; Schmidt, Terri; Christenson, Jim.

In: Resuscitation, Vol. 85, No. 3, 03.2014, p. 336-342.

Research output: Contribution to journalArticle

Cheskes, S, Schmicker, RH, Verbeek, PR, Salcido, DD, Brown, SP, Brooks, S, Menegazzi, JJ, Vaillancourt, C, Powell, J, May, S, Berg, RA, Sell, R, Idris, A, Kampp, M, Schmidt, T & Christenson, J 2014, 'The impact of peri-shock pause on survival from out-of-hospital shockable cardiac arrest during the Resuscitation Outcomes Consortium PRIMED trial', Resuscitation, vol. 85, no. 3, pp. 336-342. https://doi.org/10.1016/j.resuscitation.2013.10.014
Cheskes, Sheldon ; Schmicker, Robert H. ; Verbeek, P. Richard ; Salcido, David D. ; Brown, Siobhan P. ; Brooks, Steven ; Menegazzi, James J. ; Vaillancourt, Christian ; Powell, Judy ; May, Susanne ; Berg, Robert A. ; Sell, Rebecca ; Idris, Ahamed ; Kampp, Mike ; Schmidt, Terri ; Christenson, Jim. / The impact of peri-shock pause on survival from out-of-hospital shockable cardiac arrest during the Resuscitation Outcomes Consortium PRIMED trial. In: Resuscitation. 2014 ; Vol. 85, No. 3. pp. 336-342.
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abstract = "Background: Previous research has demonstrated significant relationships between peri-shock pause and survival to discharge from out-of-hospital shockable cardiac arrest (OHCA). Objective: To determine the impact of peri-shock pause on survival from OHCA during the ROC PRIMED randomized controlled trial. Methods: We included patients in the ROC PRIMED trial who suffered OHCA between June 2007 and November 2009, presented with a shockable rhythm and had CPR process data for at least one shock. We used multivariable logistic regression to determine the association between peri-shock pause duration and survival to hospital discharge. Results: Among 2006 patients studied, the median (IQR) shock pause duration was: pre-shock pause 15. s (8, 22); post-shock pause 6. s (4, 9); and peri-shock pause 22.0. s (14, 31). After adjusting for Utstein predictors of survival as well as CPR quality measures, the odds of survival to hospital discharge were significantly higher for patients with pre-shock pause <10. s (OR: 1.52, 95{\%} CI: 1.09, 2.11) and peri-shock pause <20. s (OR: 1.82, 95{\%} CI: 1.17, 2.85) when compared to patients with pre-shock pause ≥20. s and peri-shock pause ≥40. s. Post-shock pause was not significantly associated with survival to hospital discharge. Results for neurologically intact survival (Modified Rankin Score. ≤. 3) were similar to our primary outcome. Conclusions: In patients with cardiac arrest presenting in a shockable rhythm during the ROC PRIMED trial, shorter pre- and peri-shock pauses were significantly associated with higher odds of survival. Future cardiopulmonary education and technology should focus on minimizing all peri-shock pauses.",
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AU - Schmicker, Robert H.

AU - Verbeek, P. Richard

AU - Salcido, David D.

AU - Brown, Siobhan P.

AU - Brooks, Steven

AU - Menegazzi, James J.

AU - Vaillancourt, Christian

AU - Powell, Judy

AU - May, Susanne

AU - Berg, Robert A.

AU - Sell, Rebecca

AU - Idris, Ahamed

AU - Kampp, Mike

AU - Schmidt, Terri

AU - Christenson, Jim

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N2 - Background: Previous research has demonstrated significant relationships between peri-shock pause and survival to discharge from out-of-hospital shockable cardiac arrest (OHCA). Objective: To determine the impact of peri-shock pause on survival from OHCA during the ROC PRIMED randomized controlled trial. Methods: We included patients in the ROC PRIMED trial who suffered OHCA between June 2007 and November 2009, presented with a shockable rhythm and had CPR process data for at least one shock. We used multivariable logistic regression to determine the association between peri-shock pause duration and survival to hospital discharge. Results: Among 2006 patients studied, the median (IQR) shock pause duration was: pre-shock pause 15. s (8, 22); post-shock pause 6. s (4, 9); and peri-shock pause 22.0. s (14, 31). After adjusting for Utstein predictors of survival as well as CPR quality measures, the odds of survival to hospital discharge were significantly higher for patients with pre-shock pause <10. s (OR: 1.52, 95% CI: 1.09, 2.11) and peri-shock pause <20. s (OR: 1.82, 95% CI: 1.17, 2.85) when compared to patients with pre-shock pause ≥20. s and peri-shock pause ≥40. s. Post-shock pause was not significantly associated with survival to hospital discharge. Results for neurologically intact survival (Modified Rankin Score. ≤. 3) were similar to our primary outcome. Conclusions: In patients with cardiac arrest presenting in a shockable rhythm during the ROC PRIMED trial, shorter pre- and peri-shock pauses were significantly associated with higher odds of survival. Future cardiopulmonary education and technology should focus on minimizing all peri-shock pauses.

AB - Background: Previous research has demonstrated significant relationships between peri-shock pause and survival to discharge from out-of-hospital shockable cardiac arrest (OHCA). Objective: To determine the impact of peri-shock pause on survival from OHCA during the ROC PRIMED randomized controlled trial. Methods: We included patients in the ROC PRIMED trial who suffered OHCA between June 2007 and November 2009, presented with a shockable rhythm and had CPR process data for at least one shock. We used multivariable logistic regression to determine the association between peri-shock pause duration and survival to hospital discharge. Results: Among 2006 patients studied, the median (IQR) shock pause duration was: pre-shock pause 15. s (8, 22); post-shock pause 6. s (4, 9); and peri-shock pause 22.0. s (14, 31). After adjusting for Utstein predictors of survival as well as CPR quality measures, the odds of survival to hospital discharge were significantly higher for patients with pre-shock pause <10. s (OR: 1.52, 95% CI: 1.09, 2.11) and peri-shock pause <20. s (OR: 1.82, 95% CI: 1.17, 2.85) when compared to patients with pre-shock pause ≥20. s and peri-shock pause ≥40. s. Post-shock pause was not significantly associated with survival to hospital discharge. Results for neurologically intact survival (Modified Rankin Score. ≤. 3) were similar to our primary outcome. Conclusions: In patients with cardiac arrest presenting in a shockable rhythm during the ROC PRIMED trial, shorter pre- and peri-shock pauses were significantly associated with higher odds of survival. Future cardiopulmonary education and technology should focus on minimizing all peri-shock pauses.

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KW - Heart arrest

KW - Resuscitation

KW - Survival

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