Abstract
Race and ethnic backgrounds affect the disease characteristics and clinical outcomes in many cancers, including acute myeloid leukemia; however, the association of race/ethnicity on myelodysplastic syndrome (MDS) is still controversial. Therefore, we aimed to study the impact of race/ethnicity on the disease characteristics and survival outcomes in patients with MDS. Adult patients with MDS diagnosed in 2004–2016 were selected using the SEER database. Race/ethnicity was categorized as non-Hispanic White (NHW), non-Hispanic Black (NHB), and Hispanic. Hispanic and NHB patients had significantly lower incidence rate ratio (IRR) in age group ≥01 years (p <.001) compared to NHW; however, in the age group <50 years, NHB patients had significantly higher IRR with an increased incidence rate of 49%. NHB patients had better overall survival than Hispanic and NHW patients (p <.001), even after adjusting for confounding variables. MDS have significant differences in age at diagnosis, disease risk, and survival outcomes based on racial/ethnic backgrounds.
Original language | English (US) |
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Pages (from-to) | 1651-1659 |
Number of pages | 9 |
Journal | Leukemia and Lymphoma |
Volume | 63 |
Issue number | 7 |
DOIs | |
State | Published - 2022 |
Keywords
- Myelodysplastic syndromes
- ethnicity
- incidence
- national database
- race
- survival analysis
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research