The impact of race and ethnicity on outcomes of patients with myelodysplastic syndromes: a population-based analysis

Suleyman Yasin Goksu, Muhammet Ozer, Busra B. Goksu, Rong Wang, Jude Khatib, Prapti A Patel, Madhuri Vusirikala, Suzanne Cole, Ahmet Seyhanli, Robert H. Collins, Stephen Chung, Amer M. Zeidan, Yazan F. Madanat

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Race and ethnic backgrounds affect the disease characteristics and clinical outcomes in many cancers, including acute myeloid leukemia; however, the association of race/ethnicity on myelodysplastic syndrome (MDS) is still controversial. Therefore, we aimed to study the impact of race/ethnicity on the disease characteristics and survival outcomes in patients with MDS. Adult patients with MDS diagnosed in 2004–2016 were selected using the SEER database. Race/ethnicity was categorized as non-Hispanic White (NHW), non-Hispanic Black (NHB), and Hispanic. Hispanic and NHB patients had significantly lower incidence rate ratio (IRR) in age group ≥01 years (p <.001) compared to NHW; however, in the age group <50 years, NHB patients had significantly higher IRR with an increased incidence rate of 49%. NHB patients had better overall survival than Hispanic and NHW patients (p <.001), even after adjusting for confounding variables. MDS have significant differences in age at diagnosis, disease risk, and survival outcomes based on racial/ethnic backgrounds.

Original languageEnglish (US)
JournalLeukemia and Lymphoma
DOIs
StateAccepted/In press - 2022

Keywords

  • Myelodysplastic syndromes
  • ethnicity
  • incidence
  • national database
  • race
  • survival analysis

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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