The impact on health-related quality of life from non-steroidal anti-inflammatory drugs, methotrexate, or steroids in treatment for juvenile idiopathic arthritis

Russ Riddle, Christina N. Ryser, Anne A. Morton, J. D. Sampson, Richard H. Browne, Marilynn G. Punaro, Robert J. Gatchel

Research output: Contribution to journalArticle

10 Scopus citations


Objective: To assess and compare the impact of medication treatments on health-related quality of life (HRQOL), family function, and medical status in children with juvenile idiopathic arthritis (JIA). Methods: Fifty-seven children diagnosed with JIA were assessed by a pediatric rheumatologist and placed into one of three treatment groups: (1) non-steroidal anti-inflammatory; (2) methotrexate; or (3) steroids via IV methylprednisolone. Questionnaires were administered at baseline and 4-month follow-up. The attending pediatric rheumatologist provided additional medical information. Results: Data document the impact of JIA on HRQOL, particularly on physical and pain domains. Steroid patients experienced improved HRQOL at follow-up relative to other groups, despite reporting more problems with side effects. Conclusion: These results demonstrate positive benefits of steroids in treating JIA children, despite the greatest incidence of adverse side effects.

Original languageEnglish (US)
Pages (from-to)262-271
Number of pages10
JournalJournal of pediatric psychology
Issue number3
StatePublished - Apr 1 2006



  • Health-related quality of life
  • Juvenile arthritis
  • Outcomes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental and Educational Psychology

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