TY - JOUR
T1 - The Implementation of Ablative Hypofractionated Radiotherapy for Stereotactic Treatments in the Brain and Body
T2 - Observations on Efficacy and Toxicity in Clinical Practice
AU - Nedzi, Lucien A.
PY - 2008/10
Y1 - 2008/10
N2 - Radiosurgery has a long history dating back to the 1950s. Only in the last decade or so have advances in radiation delivery and visualization allowed export of this paradigm to extracranial sites. This review evaluates the efficacy and safety of such ablative radiation courses using dose per fraction schedules of 10 Gy or above. Retrospective published experience in functional and benign tumor radiosurgery is reviewed. Prospective controlled clinical trials in ablative cancer therapy of early-stage lung cancer and metastatic disease in the brain, liver, and spine are reviewed.
AB - Radiosurgery has a long history dating back to the 1950s. Only in the last decade or so have advances in radiation delivery and visualization allowed export of this paradigm to extracranial sites. This review evaluates the efficacy and safety of such ablative radiation courses using dose per fraction schedules of 10 Gy or above. Retrospective published experience in functional and benign tumor radiosurgery is reviewed. Prospective controlled clinical trials in ablative cancer therapy of early-stage lung cancer and metastatic disease in the brain, liver, and spine are reviewed.
UR - http://www.scopus.com/inward/record.url?scp=49749121840&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=49749121840&partnerID=8YFLogxK
U2 - 10.1016/j.semradonc.2008.04.009
DO - 10.1016/j.semradonc.2008.04.009
M3 - Article
C2 - 18725114
AN - SCOPUS:49749121840
SN - 1053-4296
VL - 18
SP - 265
EP - 272
JO - Seminars in Radiation Oncology
JF - Seminars in Radiation Oncology
IS - 4
ER -