The Implementation of Ablative Hypofractionated Radiotherapy for Stereotactic Treatments in the Brain and Body: Observations on Efficacy and Toxicity in Clinical Practice

Research output: Contribution to journalArticle

14 Scopus citations


Radiosurgery has a long history dating back to the 1950s. Only in the last decade or so have advances in radiation delivery and visualization allowed export of this paradigm to extracranial sites. This review evaluates the efficacy and safety of such ablative radiation courses using dose per fraction schedules of 10 Gy or above. Retrospective published experience in functional and benign tumor radiosurgery is reviewed. Prospective controlled clinical trials in ablative cancer therapy of early-stage lung cancer and metastatic disease in the brain, liver, and spine are reviewed.

Original languageEnglish (US)
Pages (from-to)265-272
Number of pages8
JournalSeminars in Radiation Oncology
Issue number4
Publication statusPublished - Oct 2008


ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Radiation

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