As the properties of more and more isoforms of the molecules involved in G-protein-mediated signal transduction pathways are unravelled, surprising diversity and versatility are being revealed. The path from receptor to effector is not dictated exclusivelt by the α subunits of heterotrimetric G proteins. The nature of the βλ subunit complex probably controls interactions of Gα with receptors. In addition, dissociation of Gα-GTP from Gβλprovides two signalling complexes, and these proteins regulate effectors independently or synergistically. Synergistic or conditional regulation of effectors by Gα and Gβλcan provide a molecular signal that records the association of independent events.
ASJC Scopus subject areas
- Cell Biology