The importance of G-protein βλ subunits

Jorge Iñiguez-Lluhi, Christiane Kleuss, Alfred G. Gilman

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

As the properties of more and more isoforms of the molecules involved in G-protein-mediated signal transduction pathways are unravelled, surprising diversity and versatility are being revealed. The path from receptor to effector is not dictated exclusivelt by the α subunits of heterotrimetric G proteins. The nature of the βλ subunit complex probably controls interactions of Gα with receptors. In addition, dissociation of Gα-GTP from Gβλprovides two signalling complexes, and these proteins regulate effectors independently or synergistically. Synergistic or conditional regulation of effectors by Gα and Gβλcan provide a molecular signal that records the association of independent events.

Original languageEnglish (US)
Pages (from-to)230-236
Number of pages7
JournalTrends in Cell Biology
Volume3
Issue number7
DOIs
StatePublished - 1993

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Protein Subunits
GTP-Binding Proteins
Guanosine Triphosphate
Signal Transduction
Protein Isoforms
Proteins

ASJC Scopus subject areas

  • Cell Biology

Cite this

Iñiguez-Lluhi, J., Kleuss, C., & Gilman, A. G. (1993). The importance of G-protein βλ subunits. Trends in Cell Biology, 3(7), 230-236. https://doi.org/10.1016/0962-8924(93)90122-H

The importance of G-protein βλ subunits. / Iñiguez-Lluhi, Jorge; Kleuss, Christiane; Gilman, Alfred G.

In: Trends in Cell Biology, Vol. 3, No. 7, 1993, p. 230-236.

Research output: Contribution to journalArticle

Iñiguez-Lluhi, J, Kleuss, C & Gilman, AG 1993, 'The importance of G-protein βλ subunits', Trends in Cell Biology, vol. 3, no. 7, pp. 230-236. https://doi.org/10.1016/0962-8924(93)90122-H
Iñiguez-Lluhi, Jorge ; Kleuss, Christiane ; Gilman, Alfred G. / The importance of G-protein βλ subunits. In: Trends in Cell Biology. 1993 ; Vol. 3, No. 7. pp. 230-236.
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