The importance of G-protein βλ subunits

Jorge Iñiguez-Lluhi, Christiane Kleuss, Alfred G. Gilman

Research output: Contribution to journalReview article

109 Scopus citations


As the properties of more and more isoforms of the molecules involved in G-protein-mediated signal transduction pathways are unravelled, surprising diversity and versatility are being revealed. The path from receptor to effector is not dictated exclusivelt by the α subunits of heterotrimetric G proteins. The nature of the βλ subunit complex probably controls interactions of Gα with receptors. In addition, dissociation of Gα-GTP from Gβλprovides two signalling complexes, and these proteins regulate effectors independently or synergistically. Synergistic or conditional regulation of effectors by Gα and Gβλcan provide a molecular signal that records the association of independent events.

Original languageEnglish (US)
Pages (from-to)230-236
Number of pages7
JournalTrends in Cell Biology
Issue number7
StatePublished - Jul 1993


ASJC Scopus subject areas

  • Cell Biology

Cite this

Iñiguez-Lluhi, J., Kleuss, C., & Gilman, A. G. (1993). The importance of G-protein βλ subunits. Trends in Cell Biology, 3(7), 230-236.