The importance of G-protein βλ subunits

Jorge Iñiguez-Lluhi, Christiane Kleuss, Alfred G. Gilman

Research output: Contribution to journalReview articlepeer-review

109 Scopus citations

Abstract

As the properties of more and more isoforms of the molecules involved in G-protein-mediated signal transduction pathways are unravelled, surprising diversity and versatility are being revealed. The path from receptor to effector is not dictated exclusivelt by the α subunits of heterotrimetric G proteins. The nature of the βλ subunit complex probably controls interactions of Gα with receptors. In addition, dissociation of Gα-GTP from Gβλprovides two signalling complexes, and these proteins regulate effectors independently or synergistically. Synergistic or conditional regulation of effectors by Gα and Gβλcan provide a molecular signal that records the association of independent events.

Original languageEnglish (US)
Pages (from-to)230-236
Number of pages7
JournalTrends in Cell Biology
Volume3
Issue number7
DOIs
StatePublished - Jul 1993

ASJC Scopus subject areas

  • Cell Biology

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