TY - JOUR
T1 - The importance of G-protein βλ subunits
AU - Iñiguez-Lluhi, Jorge
AU - Kleuss, Christiane
AU - Gilman, Alfred G.
PY - 1993/7
Y1 - 1993/7
N2 - As the properties of more and more isoforms of the molecules involved in G-protein-mediated signal transduction pathways are unravelled, surprising diversity and versatility are being revealed. The path from receptor to effector is not dictated exclusivelt by the α subunits of heterotrimetric G proteins. The nature of the βλ subunit complex probably controls interactions of Gα with receptors. In addition, dissociation of Gα-GTP from Gβλprovides two signalling complexes, and these proteins regulate effectors independently or synergistically. Synergistic or conditional regulation of effectors by Gα and Gβλcan provide a molecular signal that records the association of independent events.
AB - As the properties of more and more isoforms of the molecules involved in G-protein-mediated signal transduction pathways are unravelled, surprising diversity and versatility are being revealed. The path from receptor to effector is not dictated exclusivelt by the α subunits of heterotrimetric G proteins. The nature of the βλ subunit complex probably controls interactions of Gα with receptors. In addition, dissociation of Gα-GTP from Gβλprovides two signalling complexes, and these proteins regulate effectors independently or synergistically. Synergistic or conditional regulation of effectors by Gα and Gβλcan provide a molecular signal that records the association of independent events.
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U2 - 10.1016/0962-8924(93)90122-H
DO - 10.1016/0962-8924(93)90122-H
M3 - Review article
AN - SCOPUS:0027253711
SN - 0962-8924
VL - 3
SP - 230
EP - 236
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 7
ER -