The Importance of Melanocortin Receptors and Their Agonists in Pulmonary Disease

Anna Elizabeth Moscowitz; Huda Asif; Laurence Baily Lindenmaier; Andrew Calzadilla; Chongxu Zhang; Mehdi Mirsaeidi

doi:10.3389/fmed.2019.00145

The Importance of Melanocortin Receptors and Their Agonists in Pulmonary Disease

Anna Elizabeth Moscowitz, Huda Asif, Laurence Baily Lindenmaier, Andrew Calzadilla, Chongxu Zhang, Mehdi Mirsaeidi

Research output: Contribution to journal › Review article › peer-review

25 Scopus citations

Abstract

Melanocortin agonists are ancient neuropeptides that have steroidogenesis and anti-inflammatory properties. They activate melanocortin receptors (MCR), a family of five seven-transmembrane G-protein coupled receptors. MC1R and MC3R are mainly involved in immunomodulatory effects. Adrenocorticotropin hormone (ACTH) and alpha-Melanocortin stimulating hormone (α-MSH) reduce pro-inflammatory cytokines in several pulmonary inflammatory disorders including asthma, sarcoidosis, and the acute respiratory distress syndrome. They have also been shown to reduce fibrogenesis in animal models with pulmonary fibrosis. By understanding the functions of MCR in macrophages, T-helper cell type 1, and T-helper cell type 17, we may uncover the mechanism of action of melanocortin agonists in sarcoidosis. Further translational and clinical research is needed to define the role of ACTH and α-MSH in pulmonary diseases.

Original language	English (US)
Article number	145
Journal	Frontiers in Medicine
Volume	6
DOIs	https://doi.org/10.3389/fmed.2019.00145
State	Published - Jun 27 2019
Externally published	Yes

Keywords

ACTH
MCR
melanocortin
sarcoidosis
α-MSH

ASJC Scopus subject areas

General Medicine

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10.3389/fmed.2019.00145

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title = "The Importance of Melanocortin Receptors and Their Agonists in Pulmonary Disease",

abstract = "Melanocortin agonists are ancient neuropeptides that have steroidogenesis and anti-inflammatory properties. They activate melanocortin receptors (MCR), a family of five seven-transmembrane G-protein coupled receptors. MC1R and MC3R are mainly involved in immunomodulatory effects. Adrenocorticotropin hormone (ACTH) and alpha-Melanocortin stimulating hormone (α-MSH) reduce pro-inflammatory cytokines in several pulmonary inflammatory disorders including asthma, sarcoidosis, and the acute respiratory distress syndrome. They have also been shown to reduce fibrogenesis in animal models with pulmonary fibrosis. By understanding the functions of MCR in macrophages, T-helper cell type 1, and T-helper cell type 17, we may uncover the mechanism of action of melanocortin agonists in sarcoidosis. Further translational and clinical research is needed to define the role of ACTH and α-MSH in pulmonary diseases.",

keywords = "ACTH, MCR, melanocortin, sarcoidosis, α-MSH",

author = "Moscowitz, {Anna Elizabeth} and Huda Asif and Lindenmaier, {Laurence Baily} and Andrew Calzadilla and Chongxu Zhang and Mehdi Mirsaeidi",

note = "Funding Information: Funding. This work was supported in part by Health Resources and Services Administration contract 234-2005-37011C, and Mallinckrodt Pharmaceuticals for research grant support. The content is the responsibility of the authors alone and does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2019 Moscowitz, Asif, Lindenmaier, Calzadilla, Zhang and Mirsaeidi.",

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AU - Moscowitz, Anna Elizabeth

AU - Asif, Huda

AU - Lindenmaier, Laurence Baily

AU - Calzadilla, Andrew

AU - Zhang, Chongxu

AU - Mirsaeidi, Mehdi

N1 - Funding Information: Funding. This work was supported in part by Health Resources and Services Administration contract 234-2005-37011C, and Mallinckrodt Pharmaceuticals for research grant support. The content is the responsibility of the authors alone and does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. Publisher Copyright: © Copyright © 2019 Moscowitz, Asif, Lindenmaier, Calzadilla, Zhang and Mirsaeidi.

PY - 2019/6/27

Y1 - 2019/6/27

N2 - Melanocortin agonists are ancient neuropeptides that have steroidogenesis and anti-inflammatory properties. They activate melanocortin receptors (MCR), a family of five seven-transmembrane G-protein coupled receptors. MC1R and MC3R are mainly involved in immunomodulatory effects. Adrenocorticotropin hormone (ACTH) and alpha-Melanocortin stimulating hormone (α-MSH) reduce pro-inflammatory cytokines in several pulmonary inflammatory disorders including asthma, sarcoidosis, and the acute respiratory distress syndrome. They have also been shown to reduce fibrogenesis in animal models with pulmonary fibrosis. By understanding the functions of MCR in macrophages, T-helper cell type 1, and T-helper cell type 17, we may uncover the mechanism of action of melanocortin agonists in sarcoidosis. Further translational and clinical research is needed to define the role of ACTH and α-MSH in pulmonary diseases.

AB - Melanocortin agonists are ancient neuropeptides that have steroidogenesis and anti-inflammatory properties. They activate melanocortin receptors (MCR), a family of five seven-transmembrane G-protein coupled receptors. MC1R and MC3R are mainly involved in immunomodulatory effects. Adrenocorticotropin hormone (ACTH) and alpha-Melanocortin stimulating hormone (α-MSH) reduce pro-inflammatory cytokines in several pulmonary inflammatory disorders including asthma, sarcoidosis, and the acute respiratory distress syndrome. They have also been shown to reduce fibrogenesis in animal models with pulmonary fibrosis. By understanding the functions of MCR in macrophages, T-helper cell type 1, and T-helper cell type 17, we may uncover the mechanism of action of melanocortin agonists in sarcoidosis. Further translational and clinical research is needed to define the role of ACTH and α-MSH in pulmonary diseases.

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KW - sarcoidosis

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The Importance of Melanocortin Receptors and Their Agonists in Pulmonary Disease

Abstract

Keywords

ASJC Scopus subject areas

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