TY - JOUR
T1 - The importance of water exchange rates in the design of responsive agents for MRI
AU - Sherry, A. Dean
AU - Wu, Yunkou
PY - 2013/4
Y1 - 2013/4
N2 - The rate of water exchange in lanthanide complexes is often overlooked as an important parameter in the design of responsive MR imaging agents. Most often, the number of inner-sphere water coordination sites or the rotational mobility of the complex is considered as the central theme while water exchange is either assumed to be " fast enough" or entirely ignored. On the contrary, relaxation and shift theories predict that water exchange rates may indeed be the key parameter one should consider in any new molecular design. In this short review, the impact of water exchange rates on three classes of lanthanide-based MRI contrast agents, T1-based relaxation agents, T2 exchange line-broadening agents and chemical exchange saturation transfer (CEST) agents, is illustrated and discussed.
AB - The rate of water exchange in lanthanide complexes is often overlooked as an important parameter in the design of responsive MR imaging agents. Most often, the number of inner-sphere water coordination sites or the rotational mobility of the complex is considered as the central theme while water exchange is either assumed to be " fast enough" or entirely ignored. On the contrary, relaxation and shift theories predict that water exchange rates may indeed be the key parameter one should consider in any new molecular design. In this short review, the impact of water exchange rates on three classes of lanthanide-based MRI contrast agents, T1-based relaxation agents, T2 exchange line-broadening agents and chemical exchange saturation transfer (CEST) agents, is illustrated and discussed.
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U2 - 10.1016/j.cbpa.2012.12.012
DO - 10.1016/j.cbpa.2012.12.012
M3 - Review article
C2 - 23333571
AN - SCOPUS:84876736794
SN - 1367-5931
VL - 17
SP - 167
EP - 174
JO - Current Opinion in Chemical Biology
JF - Current Opinion in Chemical Biology
IS - 2
ER -