The inactivation of the XP-C gene does not affect somatic hypermutation or class switch recombination of immunoglobulin genes

Hong Ming Shen, David L. Cheo, Errol Friedberg, Ursula Storb

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

The mechanism of somatic hypermutation of immunoglobulin genes is not known, but appears to be linked to transcription and perhaps DNA repair. In order to determine if global DNA repair or the repair of the nontranscribed DNA strand is required for somatic mutation, we have analysed mice whose XP- C gene was inactivated by homologous recombination. Our study shows that hypermutation occurs in XP-C knockout mice with a normal frequency, suggesting that the XP-C gene product is not required for somatic hypermutation. Furthermore, we found that Ig gene switch recombination also is normal in these mice.

Original languageEnglish (US)
Pages (from-to)527-533
Number of pages7
JournalMolecular Immunology
Volume34
Issue number7
DOIs
StatePublished - May 1997

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Keywords

  • DNA repair
  • Immunoglobulin genes
  • Somatic mutation

ASJC Scopus subject areas

  • Molecular Biology
  • Immunology

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