TY - JOUR
T1 - The incidence of new onset congestive heart failure and heart failure exacerbation in Veteran's Affairs patients receiving tumor necrosis factor alpha antagonists
AU - Cole, Jennifer
AU - Busti, Anthony
AU - Kazi, Salahuddin
PY - 2007/2
Y1 - 2007/2
N2 - The objective of this study was to evaluate the incidence of new onset or worsening congestive heart failure in Veteran's Affairs (VA) patients who have received infliximab, etanercept, or adalimumab, and to compare mortality rates in these patients to control populations. We enrolled three groups of patients for this retrospective study: TNF-α group (n = 103), a rheumatoid arthritis (RA) control group (n = 100), and a control group without RA (n = 100). All patients at our VA facility who had received at least one dose of the TNF-α antagonists were included in the TNF-α group. Admissions for CHF did not differ between the three groups: TNF-α 7 (6.7%), RA control 8 (8%), non-RA control 7 (7%); P = 0.940. Mortality rates were not significantly different: TNF-α 4 (3.8%), RA control 7 (7%), non-RA control 11 (11%); P = 0.147. Our study showed no difference between the three groups in either CHF exacerbation or mortality.
AB - The objective of this study was to evaluate the incidence of new onset or worsening congestive heart failure in Veteran's Affairs (VA) patients who have received infliximab, etanercept, or adalimumab, and to compare mortality rates in these patients to control populations. We enrolled three groups of patients for this retrospective study: TNF-α group (n = 103), a rheumatoid arthritis (RA) control group (n = 100), and a control group without RA (n = 100). All patients at our VA facility who had received at least one dose of the TNF-α antagonists were included in the TNF-α group. Admissions for CHF did not differ between the three groups: TNF-α 7 (6.7%), RA control 8 (8%), non-RA control 7 (7%); P = 0.940. Mortality rates were not significantly different: TNF-α 4 (3.8%), RA control 7 (7%), non-RA control 11 (11%); P = 0.147. Our study showed no difference between the three groups in either CHF exacerbation or mortality.
KW - Congestive
KW - Heart failure
KW - Rheumatoid arthritis
KW - Tumor necrosis factor
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U2 - 10.1007/s00296-006-0215-3
DO - 10.1007/s00296-006-0215-3
M3 - Article
C2 - 17028862
AN - SCOPUS:33846278750
SN - 0172-8172
VL - 27
SP - 369
EP - 373
JO - Rheumatology International
JF - Rheumatology International
IS - 4
ER -