The inconsistent effects of calcium supplements upon blood pressure in primary hypertension

R. B. Meese, D. G. Gonzales, J. M. Casparian, C. V S Ram, M. Pak Ch., Norman M Kaplan

Research output: Contribution to journalArticle

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Abstract

The effects of 800 mg of elemental calcium per day (calcium carbonate or calcium citrate) on blood pressure were compared with a placebo in a controlled randomized, crossover, double-blinded trial involving 26 patients with uncomplicated primary hypertension. Each patient took two of the three forms of therapy orally for 8-week intervals with a 2-week washout period in between. Standing mean blood pressure rose an average of 5.7 mm Hg on placebo, rose an overage of 0.5 mm Hg on calcium carbonate, and fell an average of 2.2 mm Hg on calcium citrate. Changes in sitting mean pressures averaged +1.9 mm Hg on placebo, -0.4 mm Hg on calcium carbonate, and -0.4 mm Hg on calcium citrate. Some patients had a fall, others had a rise in blood pressure on each form of calcium. Similarly, inconsistent responses were noted among the nine patients who took both forms of calcium. Neither initial nor post-treatment biochemical measures nor patient characteristics were predictive of the blood pressure response. Combinations of various measures and characteristics analyzed by the multiple regression technique explained only 30% of the overall variability in blood pressure. Therefore, until ways can be found to predict the response, calcium supplements should not be routinely prescribed for the treatment of hypertension and, if given for any indication, blood pressure should be monitored.

Original languageEnglish (US)
Pages (from-to)219-224
Number of pages6
JournalAmerican Journal of the Medical Sciences
Volume294
Issue number4
StatePublished - 1987

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Calcium Citrate
Blood Pressure
Hypertension
Calcium
Calcium Carbonate
Placebos
Therapeutics
Pressure

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Meese, R. B., Gonzales, D. G., Casparian, J. M., Ram, C. V. S., Pak Ch., M., & Kaplan, N. M. (1987). The inconsistent effects of calcium supplements upon blood pressure in primary hypertension. American Journal of the Medical Sciences, 294(4), 219-224.

The inconsistent effects of calcium supplements upon blood pressure in primary hypertension. / Meese, R. B.; Gonzales, D. G.; Casparian, J. M.; Ram, C. V S; Pak Ch., M.; Kaplan, Norman M.

In: American Journal of the Medical Sciences, Vol. 294, No. 4, 1987, p. 219-224.

Research output: Contribution to journalArticle

Meese, RB, Gonzales, DG, Casparian, JM, Ram, CVS, Pak Ch., M & Kaplan, NM 1987, 'The inconsistent effects of calcium supplements upon blood pressure in primary hypertension', American Journal of the Medical Sciences, vol. 294, no. 4, pp. 219-224.
Meese RB, Gonzales DG, Casparian JM, Ram CVS, Pak Ch. M, Kaplan NM. The inconsistent effects of calcium supplements upon blood pressure in primary hypertension. American Journal of the Medical Sciences. 1987;294(4):219-224.
Meese, R. B. ; Gonzales, D. G. ; Casparian, J. M. ; Ram, C. V S ; Pak Ch., M. ; Kaplan, Norman M. / The inconsistent effects of calcium supplements upon blood pressure in primary hypertension. In: American Journal of the Medical Sciences. 1987 ; Vol. 294, No. 4. pp. 219-224.
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