The inconvenience of convenience cohorts: Rhabdomyosarcoma and the PAX-FOXO1 biomarker

Abby R. Rosenberg, Stephen X. Skapek, Douglas S. Hawkins

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

"Convenience cohorts" comprise individuals thought to represent the general population, but chosen because they are readily available for evaluation, rather than at random. As such, these methods are subject to bias and may be misleading. Convenience cohorts have been used to investigate the prognostic significance of chromosomal translocations between the PAX3 or PAX7 and the FOXO1 genes in rhabdomyosarcoma, the most common pediatric sarcoma. However, retrospective studies assessing the role of PAX-FOXO1 translocations have yielded inconsistent results. This review highlights the findings from several clinical correlation studies of the PAX-FOXO1 biomarker and illustrates the challenges of using such methods to draw clinical conclusions.

Original languageEnglish (US)
Pages (from-to)1012-1018
Number of pages7
JournalCancer Epidemiology Biomarkers and Prevention
Volume21
Issue number7
DOIs
StatePublished - Jul 2012

Fingerprint

Rhabdomyosarcoma
Biomarkers
Genetic Translocation
Sarcoma
Retrospective Studies
Pediatrics
Population
Genes
Clinical Studies

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

The inconvenience of convenience cohorts : Rhabdomyosarcoma and the PAX-FOXO1 biomarker. / Rosenberg, Abby R.; Skapek, Stephen X.; Hawkins, Douglas S.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 21, No. 7, 07.2012, p. 1012-1018.

Research output: Contribution to journalArticle

@article{d6071b287e2e4df587d7af6659ed2baf,
title = "The inconvenience of convenience cohorts: Rhabdomyosarcoma and the PAX-FOXO1 biomarker",
abstract = "{"}Convenience cohorts{"} comprise individuals thought to represent the general population, but chosen because they are readily available for evaluation, rather than at random. As such, these methods are subject to bias and may be misleading. Convenience cohorts have been used to investigate the prognostic significance of chromosomal translocations between the PAX3 or PAX7 and the FOXO1 genes in rhabdomyosarcoma, the most common pediatric sarcoma. However, retrospective studies assessing the role of PAX-FOXO1 translocations have yielded inconsistent results. This review highlights the findings from several clinical correlation studies of the PAX-FOXO1 biomarker and illustrates the challenges of using such methods to draw clinical conclusions.",
author = "Rosenberg, {Abby R.} and Skapek, {Stephen X.} and Hawkins, {Douglas S.}",
year = "2012",
month = "7",
doi = "10.1158/1055-9965.EPI-12-0207",
language = "English (US)",
volume = "21",
pages = "1012--1018",
journal = "Cancer Epidemiology Biomarkers and Prevention",
issn = "1055-9965",
publisher = "American Association for Cancer Research Inc.",
number = "7",

}

TY - JOUR

T1 - The inconvenience of convenience cohorts

T2 - Rhabdomyosarcoma and the PAX-FOXO1 biomarker

AU - Rosenberg, Abby R.

AU - Skapek, Stephen X.

AU - Hawkins, Douglas S.

PY - 2012/7

Y1 - 2012/7

N2 - "Convenience cohorts" comprise individuals thought to represent the general population, but chosen because they are readily available for evaluation, rather than at random. As such, these methods are subject to bias and may be misleading. Convenience cohorts have been used to investigate the prognostic significance of chromosomal translocations between the PAX3 or PAX7 and the FOXO1 genes in rhabdomyosarcoma, the most common pediatric sarcoma. However, retrospective studies assessing the role of PAX-FOXO1 translocations have yielded inconsistent results. This review highlights the findings from several clinical correlation studies of the PAX-FOXO1 biomarker and illustrates the challenges of using such methods to draw clinical conclusions.

AB - "Convenience cohorts" comprise individuals thought to represent the general population, but chosen because they are readily available for evaluation, rather than at random. As such, these methods are subject to bias and may be misleading. Convenience cohorts have been used to investigate the prognostic significance of chromosomal translocations between the PAX3 or PAX7 and the FOXO1 genes in rhabdomyosarcoma, the most common pediatric sarcoma. However, retrospective studies assessing the role of PAX-FOXO1 translocations have yielded inconsistent results. This review highlights the findings from several clinical correlation studies of the PAX-FOXO1 biomarker and illustrates the challenges of using such methods to draw clinical conclusions.

UR - http://www.scopus.com/inward/record.url?scp=84863564132&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863564132&partnerID=8YFLogxK

U2 - 10.1158/1055-9965.EPI-12-0207

DO - 10.1158/1055-9965.EPI-12-0207

M3 - Article

C2 - 22564868

AN - SCOPUS:84863564132

VL - 21

SP - 1012

EP - 1018

JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

SN - 1055-9965

IS - 7

ER -