The indolent nature of pulmonary metastases from ductal adenocarcinoma of the pancreas

Stephanie Downs-Canner, Mazen Zenati, Brian A. Boone, Patrick R. Varley, Jennifer Steve, Melissa E. Hogg, Amer Zureikat, Herbert J. Zeh, Kenneth K.W. Lee

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Background and Objectives The natural history of pulmonary metastases from pancreatic ductal adenocarcinoma (PDAC) is not well studied. Limited evidence suggests patients with isolated pulmonary metastases from PDAC follow a more benign clinical course than those with other sites of metastases. Methods We performed a retrospective review of all patients with pulmonary metastases from PDAC from 2000 to 2010 and analyzed survival utilizing the Kaplan-Meier method based upon location of first metastasis (lung first, intra-abdominal first, or synchronous intra-abdominal and lung metastases). Results Median survival among subjects with lung as the only site of metastases was significantly longer than those with other metastatic patterns. In subjects that had undergone resection of their PDAC, survival in those with lung as a first site of recurrence remained significantly longer than those with abdominal first or synchronous intra-abdominal and lung recurrence. Among resected patients that developed lung only recurrence, survival was significantly prolonged (67.5 months) in those who underwent surgical resection/stereotactic radiosurgery compared to chemotherapy (33.8 months) or observation (29.9 months) for treatment of lung recurrence. Conclusion Patients with isolated pulmonary recurrence from PDAC may realize a survival benefit from surgical intervention or stereotactic radiosurgery compared to chemotherapy or observation for treatment of lung recurrence. J. Surg. Oncol. 2015 111:80-85.

Original languageEnglish (US)
Pages (from-to)80-85
Number of pages6
JournalJournal of Surgical Oncology
Volume112
Issue number1
DOIs
StatePublished - Jul 1 2015
Externally publishedYes

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Keywords

  • lung metastases
  • pancreatic ductal adenocarcinoma
  • pulmonary metastases

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Downs-Canner, S., Zenati, M., Boone, B. A., Varley, P. R., Steve, J., Hogg, M. E., Zureikat, A., Zeh, H. J., & Lee, K. K. W. (2015). The indolent nature of pulmonary metastases from ductal adenocarcinoma of the pancreas. Journal of Surgical Oncology, 112(1), 80-85. https://doi.org/10.1002/jso.23943