The induction of anterior chamber-associated immune deviation

Research output: Chapter in Book/Report/Conference proceedingChapter

50 Citations (Scopus)

Abstract

Evidence of ocular immune privilege was noted almost 130 years ago. The past 30 years have witnessed an explosion in research on ocular immune privilege. One of the primary mechanisms that contribute to ocular immune privilege is the unique form of immune deviation that is invoked when antigens are introduced into the anterior chamber (AC) of the eye - a phenomenon termed AC-associated immune deviation (ACAID). ACAID embodies a constellation of cellular interactions and at least four different organ systems: eye, thymus, spleen, and sympathetic nervous system. At least four different cell populations interact to generate CD8+ T regulatory cells that suppress both Th1- and Th2-mediated inflammation. The interactions that occur between F4/80+ antigen-presenting cells, CD4+ T regulatory cells, NK1.1+ T cells, γδ T cells, B cells, and CD8+ T cells remain to be fully elucidated. Ocular immune privilege was originally perceived as a simple anatomic anomaly that has evolved to be one of the most sophisticated and intriguing forms of immune regulation.

Original languageEnglish (US)
Title of host publicationChemical Immunology and Allergy
Pages27-35
Number of pages9
Volume92
DOIs
StatePublished - 2007

Publication series

NameChemical Immunology and Allergy
Volume92
ISSN (Print)16602242

Fingerprint

Anterior Chamber
Regulatory T-Lymphocytes
T-Lymphocytes
Explosions
Sympathetic Nervous System
Antigen-Presenting Cells
Thymus Gland
B-Lymphocytes
Spleen
Inflammation
Antigens
Research
Population

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Niederkorn, J. Y. (2007). The induction of anterior chamber-associated immune deviation. In Chemical Immunology and Allergy (Vol. 92, pp. 27-35). (Chemical Immunology and Allergy; Vol. 92). https://doi.org/10.1159/000099251

The induction of anterior chamber-associated immune deviation. / Niederkorn, Jerry Y.

Chemical Immunology and Allergy. Vol. 92 2007. p. 27-35 (Chemical Immunology and Allergy; Vol. 92).

Research output: Chapter in Book/Report/Conference proceedingChapter

Niederkorn, JY 2007, The induction of anterior chamber-associated immune deviation. in Chemical Immunology and Allergy. vol. 92, Chemical Immunology and Allergy, vol. 92, pp. 27-35. https://doi.org/10.1159/000099251
Niederkorn JY. The induction of anterior chamber-associated immune deviation. In Chemical Immunology and Allergy. Vol. 92. 2007. p. 27-35. (Chemical Immunology and Allergy). https://doi.org/10.1159/000099251
Niederkorn, Jerry Y. / The induction of anterior chamber-associated immune deviation. Chemical Immunology and Allergy. Vol. 92 2007. pp. 27-35 (Chemical Immunology and Allergy).
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