The induction of intercellular adhesion molecule 1 (ICAM-1) expression on human fetal astrocytes by interferon-λ, tumor necrosis factor α, lymphotoxin, and interleukin-1

relevance to intracerebral antigen presentation

Elliot Frohman, Teresa C. Frohman, Michael L. Dustin, Bharathi Vayuvegula, Ben Choi, Abha Gupta, Stanley van den Noort, Sudhir Gupta

Research output: Contribution to journalArticle

186 Citations (Scopus)

Abstract

Antigen presentation reactions are dependent upon the expression of the class II major histocompatibility antigens (MHC), the T-cell receptor, and the presented antigen. Recent studies demonstrate that such processes also require the presence of adhesion molecules such as lymphocyte functional antigen 1 (LFA-1) and its cell surface ligand, intercellular adhesion molecule 1 (ICAM-1). It has been suggested that the brain astrocyte can function as a facultative antigen presenting cell (APC). This hypothesis is based upon th ability to induce the expression of the class II MHC antigens on astrocytes, and on their ability to present myelin basic protein on encephalitogenic T-cells in vitro. The best in vivo data showing that astrocytes serve as intracerebral APCs is the finding that astrocytes in multiple sclerosis plaques are DR+ (class II MHC in human). However, it still remains to be resolved whether the in vivo expression of the MHC antigens in disease states is instrumental to antigen presentation mechanisms or whether these cell suface glycoproteins are expressed secondary to brain immune responses. If astrocytes function as immunocompetent APCs within the brain, it would seem that they would also be able to express molecules important for intercellular adhesion. Here, we present the first data that indicates that human astrocytes are capable of expressing ICAM-1 in response to cytokines that either induce or upregulate the expression of DR. In essence, cytokines derived from different cell types seem to exert similar pleiotropic effects on the modulation of MHC and ICAM-1 expression on astrocytes. This suggests that mechanisms critical to the initiation of brain immune responses involve a dynamic molecular interface between a variety of resident central nervous system and peripheral cell types.

Original languageEnglish (US)
Pages (from-to)117-124
Number of pages8
JournalJournal of Neuroimmunology
Volume23
Issue number2
DOIs
StatePublished - 1989

Fingerprint

Lymphotoxin-alpha
Antigen Presentation
Intercellular Adhesion Molecule-1
Interleukin-1
Astrocytes
Interferons
Tumor Necrosis Factor-alpha
Histocompatibility Antigens Class II
Histocompatibility Antigens
Brain
Antigens
Cytokines
Myelin Basic Protein
Cell Adhesion Molecules
Antigen-Presenting Cells
Molecular Dynamics Simulation
T-Cell Antigen Receptor
Multiple Sclerosis
Glycoproteins
Up-Regulation

Keywords

  • Antigen presentation
  • Astrocyte
  • Class II major histocompatibility antigen
  • Intercellular adhession molecule 1
  • Interferon-λ
  • Lymphocyte functional antigen 1

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

Cite this

The induction of intercellular adhesion molecule 1 (ICAM-1) expression on human fetal astrocytes by interferon-λ, tumor necrosis factor α, lymphotoxin, and interleukin-1 : relevance to intracerebral antigen presentation. / Frohman, Elliot; Frohman, Teresa C.; Dustin, Michael L.; Vayuvegula, Bharathi; Choi, Ben; Gupta, Abha; Noort, Stanley van den; Gupta, Sudhir.

In: Journal of Neuroimmunology, Vol. 23, No. 2, 1989, p. 117-124.

Research output: Contribution to journalArticle

Frohman, Elliot ; Frohman, Teresa C. ; Dustin, Michael L. ; Vayuvegula, Bharathi ; Choi, Ben ; Gupta, Abha ; Noort, Stanley van den ; Gupta, Sudhir. / The induction of intercellular adhesion molecule 1 (ICAM-1) expression on human fetal astrocytes by interferon-λ, tumor necrosis factor α, lymphotoxin, and interleukin-1 : relevance to intracerebral antigen presentation. In: Journal of Neuroimmunology. 1989 ; Vol. 23, No. 2. pp. 117-124.
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AU - Gupta, Sudhir

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